NRCAM Variant Defined By Microexon Skipping Is A Targetable Cell Surface Proteoform In High-Grade Gliomas

To overcome the paucity of known tumor-specific surface antigens in pediatric high-grade glioma (pHGG), we contrasted splicing patterns in pHGGs and normal brain samples. Among alternative splicing events affecting extracellular protein domains, the most pervasive alteration was the skipping of ≤30-nt-long exons.