Comparison of CBTTC patient data with molecularly defined stem cell models of pediatric brain tumors

Our goal is to understand brain tumor development and progression by identifying genes that are differentially regulated in pediatric brain tumors as compared to normal brain samples. We are currently generating animal models for specific malignant childhood brain tumors. By comparing data from our models to global patient datasets, we hope to identify gene expression patterns characteristic of different molecular entities of pediatric brain tumors.