Brainstem glioma- Diffuse intrinsic pontine glioma

Glioma

Default histology image
136

enrolled participants

name
6
Data Projects Supported
name
6
Specimen Projects Supported
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Summary of

Brainstem glioma- Diffuse intrinsic pontine glioma

A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor.[5] New approaches with stereotactic needle biopsy may make biopsy safer.[6-9] Biopsy is recommended for pontine tumors when the diagnosis is uncertain based on imaging findings.

SourceNCI

available Glioma

Resources

How many participants are enrolled?

136Participants Enrolled

Available CBTN Biospecimens

participants with flash-frozen tissue available81

participants with flash-frozen tissue available

participants with match blood34

participants with match blood

participants with match parental specimens1

participants with match parental specimens

participants with cerebral spinal fluid12

participants with cerebral spinal fluid

Available CBTN Pre-clinical Models

genomically characterized cell lines with data available1

genomically characterized cell lines with data available

genomically characterized pdx with data available0

genomically characterized pdx with data available

Projects supported by the CBTN

Data projects supported4

Data projects supported

Specimen projects supported6

Specimen projects supported

Explore the data in these informatics portals

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How do I get access to the specimens?

To request any of the biospecimens, or pre-clinical model please fill out this form.
Request take approx. 3 months and will require review by the scientific committee and MTA.
Need help? Contact us at research@cbtn.org

How do I get access to the data?

To access the data please follow these instructions. Need help? Contact us at research@cbtn.org
You can access processed data today here by simply logging in to PedcBioPortal
You can request raw data by completing this form. The review normally takes 1 week. Once approved you can access the raw data by creating cohorts of interest on the Kids First Data Resource Portal and performing analysis on the cloud in Cavatica

Flash frozen tissue is tissue from a surgical procedure where the tissue is frozen instantly in liquid nitrogen to ensure there is no degradation

Tissue in freezing media is tissue from a surgical procedure where the tissue is frozen 1 degree at a time over a 24-hour period to keep the tissue intact and compatible with regrowing the tumor for testing

Matched blood is blood that is collected from the patient in addition to tissue from the tumor. This blood provides researchers a direct comparison between normal and tumor specimens for this specific patient

Cerebral Spinal Fluid (CFS) is fluid taken from the the nervous system that researchers can use to study brain tumors

Paternal and maternal specimens are specimens taken from the biological parents of the subject. These specimens provide researchers with the ability to compare tumor and normal tissue and predispositions