Seven Bridges said on Tuesday that it has joined an international alliance that aims to link genomic cancer datasets from The Gabriella Miller Kids First Data Resource Center (Kids First DRC), Zero Childhood Cancer (Zero), the Children’s Brain Tumor Tissue Consortium (CBTTC). According to Seven Bridges, the partners aim to build a computation infrastructure that will harmonize data from Zero, an Australian initiative using genomics to personalize treatments for pediatric cancers, with the genomic datasets of CBTTC and Kids First DRC. The effort is expected to help improve researchers’ understanding of rare pediatric brain cancer subtypes.

Like so many of us during the month of September, I’ve come to regard Childhood Cancer Awareness Month as a time to take stock and reflect -- on the bravery and strength of the children and families I’ve encountered in my clinical practice, and on the progress still to be made in the struggle against childhood brain cancer.

As we continue onward, the CBTTC has officially transitioned to a new phase in our efforts on behalf of childhood brain tumor patients everywhere. Now, as the Children’s Brain Tumor Network (CBTN) we will further grow our partnerships and research efforts to CURE pediatric brain tumors through innovation, resource sharing, a commitment to global inclusion, and, most critically, through the translation of data into new clinical trials and increased clinical impact.

Comprehensive “proteogenomic” analysis of the proteins, genes, and RNA transcription involved in pediatric brain tumors could help physicians more accurately identify different types of tumors and methods for treating them.

Children’s Brain Tumor Network (CBTN) investigators from nearly all of our 25 member sites will join this global community of experts in childhood brain cancer to engage in the sharing of research and new perspectives. In addition, CBTN will give several presentations and abstracts to share our research methodology and recent discoveries.

The Children’s Brain Tumor Network (CBTN) announced an award of $1.75 million from the Swifty Foundation to accelerate pediatric brain tumor research around the globe.

We recently spoke with Dr. Chad Creighton, Professor of Medicine and Co-Director of Cancer Bioinformatics at Baylor College of Medicine, whose team utilized DNA and RNA data from hundreds of study participants within the PBTA for a major study on how Somatic Structural Variation within gene copying may drive the development of cancer cells within a child’s brain.

CBTN is working to grow its partnerships across academic, research, patient/foundation, government, and commercial spaces, with a goal of ensuring that these partners each have a clear sense of how they can advance and support the Network’s ambitious mission.

Recently, Dr. Eric B. Durbin delivered a presentation at the CBTN Investigator Meeting on his work studying cancer in Kentucky and the establishment of Kentucky ACCELERATE, a consortium that highlights how access to CBTN resources and collaborators can be transformational in expanding localized cancer research.

Oligodendroglioma is a rare form of primary malignant brain and central nervous system (CNS) cancer diagnosed in roughly 1,500 people in the United States each year. Because of its rarity, access to high-quality biospecimens and molecular data can be scarce. This has made oligodendroglioma a particularly difficult form of brain cancer for scientists to study However, CBTN has struck a unique partnership between public agencies, patient foundations, and research institutions to forge a new model for research, marking a new era in therapeutic development.

Hack4Rare event brings together partners from the aviation industry in support of children's rare-disease research.

Project will allow thousands of tissue samples to be studied and provide an enormous level of insight into childhood cancer

It is an honor to announce that Dr. Carl Koschmann, MD of the University of Michigan has been selected as the newest co-chair to the CBTN Scientific Committee. We spoke with Dr. Koschmann about his current areas of research as well as his goals in this leadership role within CBTN.

On Monday, January 31, this new and exciting collaborative effort took a critical step forward with the shipment of more than 600 samples to the Broad Institute for multi-omics sequencing. Over the next two months, the bulk of CBTN’s remaining samples, from more than 3,800 patients, will also be shipped.

The Lilabean Foundation’s support will accelerate the pace of translational research and the discovery of new treatments for children and young adults with brain tumors.

Applying a new data exchange model known as FHIR, CBTN is standardizing and automating the task of harmonizing vast amounts of data and expanding their availability across the childhood cancer research landscape.

The Carson Leslie Foundation is teaming up with CBTN to develop medulloblastoma care custom-tailored to each patient and adjustable in real time. Together, #cureMEdullo and CBTN will give doctors the absolute latest and best data to effectively treat every patient every time.

The data generated through medical research and in clinical settings are broad, complex, and collected over time, which makes putting them into a usable context more energy-intensive and time-consuming. Now, utilizing the rich data generated through CBTN, researchers are developing a new hub for standardizing data entry called the Data Tracker.

At the close of 2021, CBTN founding partners, the Kortney Rose Foundation announced their decision to close down active operations after an incredible 16 year history. CBTN is honored to share this message of reflection from pediatric brain tumor research advocate, philanthropist, parent, and co-founder of KRF, Kristen Gillette.

Project Accelerate is already underway. There are several steps to extracting the precious information we need and delivering it in a form that scientists can use in their research:

How do ecDNAs arise in human cancer? How do they promote the evolution of drug resistance in cancer cells? The answers to these questions may unlock new therapeutic strategies for pediatric patients with ecDNA+ tumors.

Indigenous leaders in medicine and research Chief Lynn Malerba, Professor Alex Brown, and Dr. Nadine Caron joined CBTN & PNOC's Dr. Cassie Kline to discuss the historical impact anti-Indigenous medical research on the modern landscape of clinical research and how Indigenous researchers are taking the health of their communities into their own hands.

Take a look back on some of the notable stories we’ve share over the last 12 months, reflecting the progress made through a shared and unceasing commitment to work together on behalf of children everywhere.

While my term as CBTN Executive Co-Chair has ended, my fervor for this effort and determination to support its continued growth remains as strong as ever. I join you in keen anticipation for all that is soon to come.

Dr. Sabine Mueller, a CBTN investigator since 2012 and co-lead of the Pacific Pediatric Neuro-Oncology Consortium (PNOC), will be expanding her involvement in CBTN’s leadership by stepping into the role of Executive Board Co-Chair, following the conclusion of Dr. Angela Waander’s tenure in this position.

Somatic mutations across over 1,800 newly characterized tumors are now available for immediate public access on PedcBioPortal.

In recognition of Childhood Brain Tumor Awareness Month, CBTN is excited to highlight a special edition of Neoplasia, which features publications from the Children's Brain Tumor Network and Pacific Pediatric Neuro-Oncology Consortium.

In a special issue of Neoplasia, CBTN and PNOC scientists and clinicians present the current state of translational and clinical research in pediatric neuro-oncology. CBTN Scientific Co-Chairs Michael Prados and Carl Koschmann provide a perspective of how far we've come - and how far we've yet to go - towards discovering better treatments for children and young adults diagnosed with a brain tumor.

Collaboration among CHOP, Alex’s Lemonade Stand Foundation, the Pacific Pediatric Neuro-Oncology Consortium, and Children’s Brain Tumor Network paves the way for new collaborative models to accelerate discoveries.

At the AWS Summit Washington, D.C. on June 9, 2023, experts from the Children’s Brain Tumor Network (CBTN), National Institutes of Health (NIH), and the White House Cancer Moonshot initiative participated in a vital panel discussion to share how a cloud-based, open-science approach drives opportunities to accelerate cancer cures. This dialog was a stand-out among more than 220 sessions that explored innovative ideas for using cloud technology to drive culture change, digital transformation, and infrastructure modernization across industries and knowledge levels.

According to the World Health Organization, over 300,000 children and adolescents under the age of 20 are diagnosed with cancer worldwide each year. In the United States, an average of 1 in every 285 children will develop cancer before the age of 20. While overall progress has been made, both nationally and internationally, brain tumors remain a leading cause of disease-related death for children and young adults. While the last several decades have seen transformative advances in biomedical research, there has been very little progress made in successfully treating and curing pediatric brain tumors. In fact there are currently no drug interventions specifically targeted for pediatric brain cancer patients.

In the realm of childhood brain tumor research, each landmark becomes a testament to the collective determination of patients, families, researchers, and institutions working together toward a common goal: developing better treatments and cures for this devastating disease. The Children's Brain Tumor Network (CBTN) has recently achieved a significant milestone by enrolling 5,000 children (and counting). In recognition of this milestone, CBTN reflects on its significance, impact, and the personal stories that unite the scientific community and patient families, fostering hope in the progress for better outcomes.

Researchers and other partners across the childhood brain tumor research community are deeply committed to discovering how to more effectively detect and treat these devastating conditions, so that no child has to suffer from a brain tumor. The Children’s Brain Tumor Network (CBTN), in partnership with the Gift from a Child (GFAC) initiative, stands as a testament to the power of collaboration to unite researchers, clinicians and patient families in the pursuit of cures. At the heart of this commitment lies the journey of tissue—one that encompasses enrollment, preservation, transformation into data, and hope for future improvements in care.

Researchers and other partners across the childhood brain tumor research community are deeply committed to discovering how to more effectively detect and treat these devastating conditions so that no child has to suffer from a brain tumor. The Children’s Brain Tumor Network (CBTN), in partnership with the Gift from a Child (GFAC) initiative, stands as a testament to the power of collaboration to unite researchers, clinicians, and patient families in the pursuit of cures. At the heart of this commitment lies the journey of tissue—one that encompasses enrollment, preservation, transformation into data, and hope for future improvements in care.

Children’s Brain Tumor Network (CBTN) welcomes Maria Fareri Children’s Hospital, a member of the Westchester Medical Center Health Network (WMCHealth) as a new member institution. CBTN membership now includes 34 leading institutions located across Europe, Asia, Australia and the United States.

With an impressive background in pediatric brain tumor research, Dr. Javad Nazarian brings a wealth of experience and a clear vision for advancing the field as the new Children’s Brain Tumor Network (CBTN) Scientific Committee Co-Chair.

As Michael Prados, MD, Scientific Executive Co-Chair of the Children's Brain Tumor Network (CBTN) steps away from his years with CBTN, it's an opportune moment to reflect on his significant contributions to CBTN, childhood brain tumor research, and the Pacific Pediatric Neuro-Oncology Consortium (PNOC). With nearly four decades of experience in Neuro-Oncology, Dr. Prados has been an unwavering force in advancing breakthroughs for brain tumors in both adults and children.

In order to manage and treat pediatric brain tumors effectively, we need innovative approaches. Traditional research methods often fall short of addressing the complexity of these diseases. In response, multidisciplinary approaches and collaborative efforts have shown promising avenues for advancing pediatric brain tumor research.

The Children's Brain Tumor Network (CBTN), a global leader in pediatric brain tumor research, shares its latest philanthropic initiative: the CBTN “Champions" tier.

Childhood cancer remains a heartbreaking reality, striking down young lives with a devastating impact. However, a powerful change-maker is stepping in to face this formidable foe: the Children’s Brain Tumor Network (CBTN) and the Center for Data-Driven Discovery in Biomedicine (D³b). This collaborative effort holds immense promise for revolutionizing diagnosis, treatments, and, ultimately, the cures for childhood brain tumors.

Children’s Brain Tumor Network (CBTN) welcomes University of Iowa Health Care Stead Family Children’s Hospital (UI) as a new member institution. CBTN membership now includes 34 leading institutions across Europe, Asia, Australia, and the United States.

Forever changed by their son's journey, Rachel Krieger and Max Horn embarked on a challenging yet transformative experience, seeking treatment at Boston Children's Hospital. It was here that music emerged as a powerful source of solace and healing for Ollie and his family. The music therapist introduced an ocean drum—something that made Ollie smile for the first time in days. This magical moment sparked an idea by Rachel’s sister in-law: what if musicians could visit the hospital to play for Ollie during his chemotherapy sessions?

Innovative and collaborative approaches are essential to effectively manage and treat pediatric brain tumors. Traditional research methods, often conducted in isolated silos, struggle to capture the complexity of these diseases. However, the emergence of the M3 Approach—multi-modal, multi-omic, and multi-disciplinary—offers promising avenues for advancing pediatric brain tumor research.

Children’s Brain Tumor Network (CBTN) welcomes Akron Children’s as a new member institution. Dr. Erin Wright, Director of Neuro-oncology at Akron Children’s, will serve as CBTN principal investigator.

CBTN has already revolutionized the pediatric brain tumor research landscape, but a recent influx of 800 new patient records is making this repository bigger, richer, and more complete. This wealth of information holds the potential to unlock new treatment options and improve patient outcomes for thousands of sick children.

Mat and Ana Johnson, founders of the Pied Piper Foundation have joined forces with the Children’s Brain Tumor Network (CBTN) Executive Council in a significant step toward finding cures for pediatric brain tumors. This strategic alliance combines a unique blend of expertise, resources, and unwavering dedication to conquering childhood cancer.

Two institutions in the city of St. Louis, are partnering to provide care for children diagnosed with brain and central nervous system tumors. Learn how tissue donation efforts at institutions throughout the Children's Brain Tumor Network are empowering researchers to better understand childhood brain tumor biology.

Thanks to the recent addition of the entire Children’s Brain Tumor Network (CBTN) dataset to the Gabriella Miller Kids First Program (Kids First) Portal, researchers now have access to a more extensive dataset on pediatric brain tumors than ever before. Since breakthroughs are more likely by continuously collecting, verifying, and making new data available to researchers studying pediatric brain tumors, this expansion is a significant step toward finding new treatments and cures.

For hundreds in the childhood brain tumor research community, the innovative, collaborative approach at the Children's Brain Tumor Network (CBTN) offers novel ways to accelerate drug discovery and advance personalized treatments for children.

The Children's Brain Tumor Network (CBTN), a consortium of leading pediatric brain tumor research institutions, announces that it has formed a groundbreaking partnership with Day One Biopharmaceuticals (Day One), a company dedicated to developing and commercializing targeted therapies for people of all ages with life-threatening diseases.

Children’s Brain Tumor Network (CBTN) welcomes Intermountain Primary Children’s Hospital (Primary Children’s Hospital) as a new member institution. The CBTN principal investigators will be Dr. Samuel Cheshier, pediatric neurosurgeon, and Dr. Nicholas Whipple, pediatric neuro-oncologist, at Huntsman Cancer Institute at University of Utah and Intermountain Primary Children’s Hospital.

Imagine a world where every child battling cancer has access to real-time, personalized treatment options. This groundbreaking vision is now closer than ever, thanks to a recent ~$10 million award from the Advanced Research Projects Agency for Health (ARPA-H) to the Center for Data Driven Discovery in Biomedicine (D3b), operations home of the Children's Brain Tumor Network (CBTN). ARPA-H, a healthcare innovation agency, is driving transformative medical advancements to tackle complex health problems. CBTN member institutions will participate in the development of this new program on several fronts, including data contribution and use as well as applications for personalized medicine.

The Children's Brain Tumor Network (CBTN), a visionary initiative dedicated to accelerating research to improve outcomes for children with brain tumors, recently achieved a significant milestone.

While researchers rightly take center stage after significant scientific breakthroughs, a dedicated group of people behind the scenes also play critical roles in the Children’s Brain Tumor Network (CBTN) success.

While researchers rightly take center stage after significant scientific breakthroughs, a dedicated group of people behind the scenes also play critical roles in the Children’s Brain Tumor Network (CBTN) success.

While researchers rightly take center stage after significant scientific breakthroughs, a dedicated group of people behind the scenes also play critical roles in the Children’s Brain Tumor Network (CBTN) success.

The Children's Brain Tumor Network (CBTN) just took another significant step forward in its search for pediatric brain tumor cures by adding the Carson Leslie Foundation to the CBTN Executive Council.

Children’s Brain Tumor Network (CBTN) welcomes Hassenfeld Children's Hospital at NYU Langone as a new member institution. The CBTN principal investigator will be Dr. Jessica Clymer, Director of the Pediatric Neuro-Oncology Program at Hassenfeld Children's Hospital.

As Executive Director of Research Operations and Strategic Planning at CHOP’s Center for Data Driven Discovery in Biomedicine (D³b) and Executive Director of the Children’s Brain Tumor Network (CBTN), Jena’s commitment to supporting pediatric cancer research has always been reflected in her work. But in recent years, she discovered an even deeper way to connect with that mission: through running.

With over $1.5 billion in funding already cut and proposed reductions, this is a crisis at the National Institutes of Health (NIH) that threatens the very foundation of research that supports resources like CBTN and Kids First need for scientists to accelerate translational impact for improved outcomes and quality of life for children. Without sustained NIH funding, critical research programs like the Gabriella Miller Kids First Pediatric Research Program—home to the Kids First Data Resource Center and CBTN Pediatric Brain Tumor Atlas (PBTA)—are at risk. We must come together to urge government leaders—at all levels—to intervene before irreversible harm is done to support these children.

Recently, a project led by Dr’s Ariana M. Familiar and Ali Nabavizadeh at the Children’s Brain Tumor Network (CBTN) published an article in the American Journal of Neuroradiology (AJNR) Imaging Publication about the development of a new tool to de-identify pediatric brain MRIs.

How Hannah, David, and the Tutu Trot Fuel Progress at CBTN.

Dr. Ammar Naqvi, a lead bioinformatics scientist at CBTN, is exploring “splicing variants,” which could open new doors in treating HGG.