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Publications

Since its launch in 2011, the CBTN (formally the Children’s Brain Tumor Tissue Consortium) has supported more than 170 studies into childhood brain and CNS tumors. The scientists who have led these studies have made a staggering number of critical discoveries, and have had their work published in some of the leading academic biomedical publications in the world. CBTN strives to have full publications made available below.

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Nature

The landscape of genomic alterations across childhood cancers

Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescen

Gröbner, Susanne N., Barbara C. Worst, Joachim Weischenfeldt, Ivo Buchhalter, Kortine Kleinheinz, Vasilisa A. Rudneva, Pascal D. Johann, Gnana Prakash Balasubramanian, Maia Segura-Wang, Sebastian Brabetz, Sebastian Bender, Barbara Hutter, Dominik Sturm, Elke Pfaff, Daniel Hübschmann, Gideon Zipprich, Michael Heinold, Jürgen Eils, Christian Lawerenz, Serap Erkek, Sander Lambo, Sebastian Waszak, Claudia Blattmann, Arndt Borkhardt, Michaela Kuhlen, Angelika Eggert, Simone Fulda, Manfred Gessler, Jenny Wegert, Roland Kappler, Daniel Baumhoer, Stefan Burdach, Renate Kirschner-Schwabe, Udo Kontny, Andreas E. Kulozik, Dietmar Lohmann, Simone Hettmer, Cornelia Eckert, Stefan Bielack, Michaela Nathrath, Charlotte Niemeyer, Günther H. Richter, Johannes Schulte, Reiner Siebert, Frank Westermann, Jan J. Molenaar, Gilles Vassal, Hendrik Witt, Icgc PedBrain-Seq Project, Icgc Mmml- Seq Project, Birgit Burkhardt, Christian P. Kratz, Olaf Witt, Cornelis M. van Tilburg, Christof M. Kramm, Gudrun Fleischhack, Uta Dirksen, Stefan Rutkowski, Michael Frühwald, Katja von Hoff, Stephan Wolf, Thomas Klingebiel, Ewa Koscielniak, Pablo Landgraf, Jan Koster, Adam C. Resnick, Jinghui Zhang, Yanling Liu, Xin Zhou, Angela J. Waanders, Danny A. Zwijnenburg, Pichai Raman, Benedikt Brors, Ursula D. Weber, Paul A. Northcott, Kristian W. Pajtler, Marcel Kool, Rosario M. Piro, Jan O. Korbel, Matthias Schlesner, Roland Eils, David T. W. Jones, Peter Lichter, Lukas Chavez, Marc Zapatka, and Stefan M. Pfister

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Cell Ecosystem and Signaling Pathways of Primary and Metastatic Pediatric Posterior Fossa Ependymoma  Figure A
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Cell

Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer

We report a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 histological types of childhood brain cancer: low-grade glioma (n = 93), ependymoma (32), high-grade glioma (25), medulloblasto

Francesca Petralia, Nicole Tignor, Boris Reva, Mateusz Koptyra, Shrabanti Chowdhury, Dmitry Rykunov, Azra Krek, Weiping Ma, Yuankun Zhu, Jiayi Ji, Anna Calinawan, Jeffrey R. Whiteaker, Antonio Colaprico, Vasileios Stathias, Tatiana Omelchenko, Xiaoyu Song, Pichai Raman, Yiran Guo, Miguel A. Brown, Richard G. Ivey, John Szpyt, Sanjukta Guha Thakurta, Marina A. Gritsenko, Karl K. Weitz, Gonzalo Lopez, Selim Kalayci, Zeynep H. Gümüş, Seungyeul Yoo, Felipe da Veiga Leprevost, Hui-Yin Chang, Karsten Krug, Lizabeth Katsnelson, Ying Wang, Jacob J. Kennedy, Uliana J. Voytovich, Lei Zhao, Krutika S. Gaonkar, Brian M. Ennis, Bo Zhang, Valerie Baubet, Lamiya Tauhid, Jena V. Lilly, Jennifer L. Mason, Bailey Farrow, Nathan Young, Sarah Leary, Jamie Moon, Vladislav A. Petyuk, Javad Nazarian, Nithin D. Adappa, James N. Palmer, Robert M. Lober, Samuel Rivero-Hinojosa, Liang-Bo Wang, Joshua M. Wang, Matilda Broberg, Rosalie K. Chu, Ronald J. Moore, Matthew E. Monroe, Rui Zhao, Richard D. Smith, Jun Zhu, Ana I. Robles, Mehdi Mesri, Emily Boja, Tara Hiltke, Henry Rodriguez, Bing Zhang, Eric E. Schadt, D.R. Mani, Li Ding, Antonio Lavarone, Maciej Wiznerowicz, Stephan Schürer, Xi S. Chen, Allison P. Heath, Jo Lynne Rokita, Alexey I. Nesvizhskii, David Fenyö, Karin D. Rodland, Tao Liu, Steven P. Gygi, Amanda G. Paulovich, Adam C. Resnick, Phillip B. Storm, Brian R. Rood, Pei Wang, Children’s Brain Tumor Network, Clinical Proteomic Tumor Analysis Consortium

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Graphic Abstract - Classification of PGs Based on Immunological Profiling
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Cell

Macrophages in SHH Subgroup Medulloblastoma Display Dynamic Heterogeneity That Varies With Treatment Modality

Tumor-associated macrophages (TAMs) play an important role in tumor immunity and comprise of subsets that have distinct phenotype, function, and ontology. Transcriptomic analyses of human medulloblastoma, the most common malignant pediatric brain cancer, showed that medulloblastomas (MBs) with activated sonic hedgehog signaling (SHH-MB) have significantly more TAMs than other MB subtypes. Therefore, we examined MB-associated TAMs by single-cell RNA sequencing of autochthonous murine SHH-MB at steady state and under two distinct treatment modalities: molecular-targeted inhibitor and radiation. Our analyses reveal significant TAM heterogeneity, identify markers of ontologically distinct TAM subsets, and show the impact of brain microenvironment on the differentiation of tumor-infiltrating monocytes. TAM composition undergoes dramatic changes with treatment and differs significantly between molecular-targeted and radiation therapy. We identify an immunosuppressive monocyte-derived TAM subset that emerges with radiation therapy and demonstrate its role in regulating T cell and neutrophil infiltration in MB.

Mai T. Dang, Michael V. Gonzalez, Krutika S. Gaonkar, Komal S. Rathi, Patricia Young, Sherjeel Arif, Li Zhai, Zahidul Alam, Samir Devalaraja, Tsun Ki Jerrick To, Ian W. Folkert, Pichai Raman, Jo Lynne Rokita, Daniel Martinez, Jaclyn N. Taroni, Joshua A. Shapiro, Casey S. Greene, Candace Savonen, Fernanda Mafra, Hakon Hakonarson, Tom Curran, Malay Haldar

Recurrent structural variants of CCDC26 in DIPG
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Cancer Cell

Proteogenomic and Metabolomic Characterization of Human Glioblastoma

Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its molecular pathogenesis is crucial to improving diagnosis and treatment. Integrated analysis of genomic, proteomic, post-translational modification and metabolomic data on 99 treatment-naive GBMs provides insights to G

Liang-BoWang, Alla Karpova, Marina A. Gritsenko, Jennifer E. Kyle, Song Cao, Yize Li, DmitryRykunov, Antonio Colaprico, Joseph H. Rothstein, Runyu Hong, Vasileios Stathias, MacIntoshCornwell, Francesca Petralia, Yige Wu, Boris Reva, Karsten Krug, Pietro Pugliese, Emily Kawaler, Lindsey K.Olsen, Wen-Wei Liang, Xiaoyu Song, Yongchao Dou, Michael C. Wendl, Wagma Caravan, Wenke Liu, Daniel Cui Zhou, Jiayi Ji, Chia-Feng Tsai, Vladislav A. Petyuk, Jamie Moon, Weiping Ma, Rosalie K. Chu, Karl K. Weitz, Ronald J.Moore, Matthew E. Monroe, Rui Zhao, Xiaolu Yang, Seungyeul Yoo, Azra Krek, Alexis Demopoulos, Houxiang Zhu, Matthew A. Wyczalkowski, Joshua F. McMichael, Brittany L. Henderson, Caleb M. Lindgren, Hannah Boekweg, Shuangjia Lu, Jessika Baral, Lijun Yao, Kelly G. Stratton, Lisa M. Bramer, Erika Zink, Sneha P. Couvillion, Kent J. Bloodsworth, Shankha Satpathy, Weiva Sieh, Simina M. Boca, Stephan Schürer, Feng Chen, Maciej Wiznerowicz, Karen A. Ketchum, Emily S. Boja, Christopher R. Kinsinger, Ana I. Robles, Tara Hiltke, Mathangi Thiagarajan, Alexey I. Nesvizhskii, Bing Zhang, D. R. Mani, Michele Ceccarelli, Xi S. Chen, Sandra L.Cottingham34Qing KayLi35Albert H.Kim36DavidFenyö, Kelly V. Ruggles, Henry Rodriguez, Mehdi Mesri, Samuel H. Payne, Adam C. Resnick, Pei Wang, Richard D. Smith, Antonio Iavarone, Milan G. Chheda, Jill S. Barnholtz-Sloan, Karin D. Rodland, Tao Liu, Li Ding, Clinical Proteomic Tumor Analysis Consortium Anupriya Agarwal, Mitual Amin, Eunkyung An, Matthew L.Anderson, David W.Andrews, Thomas Bauer, Chet Birger, Michael J.Birrer, Lili Blumenberg, William E.Bocik, Uma Borate, Melissa Borucki, Meghan C.Burke, Shuang Cai, Anna P.Calinawan, Steven A.Carr, Sandra Cerda, Daniel W.Chan, Alyssa Charamut, Lin S.Chen, David Chesla, Arul M.Chinnaiyan, ShrabantiChowdhury, Marcin P.Cieślik, David J.Clark, HoustonCulpepper, TomaszCzernicki, FulvioD'Angelo, JacobDay, Stephanie De Young, EmekDemir, Saravana Mohan, Dhanasekaran, Rajiv Dhir, Marcin J.Domagalski, BrianDruker, ElizabethDuffy, MaureenDyer, Nathan J.Edwards, RobertEdwards, KimberlyElburn, Matthew J.Ellis, JenniferEschbacher, AliciaFrancis, Stacey Gabriel, Nikolay Gabrovski, Luciano Garofano, Gad Getz, Michael A.Gillette, Andrew K.Godwin, Denis Golbin, Ziad Hanhan, Linda I.Hannick, Pushpa Hariharan, Barbara Hindenach, Katherine A.Hoadley, Galen Hostetter, Chen Huang, Eric Jaehnig, Scott D.Jewell, Nan Ji, Corbin D.Jones, Alcida Karz, Wojciech Kaspera, Lyndon Kim, Ramani B.Kothadia, Chandan Kumar-Sinha, Jonathan Lei, Felipe D.Leprevost, KaiLi, Yuxing Liao, Jena Lilly, Hongwei Liu, Jan Lubínski, Rashna Madan, William Maggio, Ewa Malc, Anna Malovannaya, Sailaja Mareedu, Sanford P.Markey, AnnetteMarrero-Oliveras, NinaMartinez, Nicollette Maunganidze, Jason E.McDermott, Peter B.McGarvey, John McGee, Piotr Mieczkowski, Simona Migliozzi, Francesmary Modugno, Rebecca Montgomery, Chelsea J.Newton, Gilbert S.Omenn, UmutOzbek, Oxana V.Paklina, Amanda G.Paulovich, Amy M.Perou, Alexander R.Pico, Paul D.Piehowski, Dimitris G.Placantonakis, LarisaPolonskaya, Olga Potapova, BarbaraPruetz, Liqun Qi, Shakti Ramkissoon, Adam Resnick, Shannon Richey, Gregory Riggins, Karna Robinson, Nancy Roche, Daniel C.Rohrer, Brian R.Rood, Larissa Rossell, Sara R.Savage, Eric E.Schadt, Yan Shi, Zhiao Shi, Yvonne Shutack, Shilpi Singh, Tara Skelly, Lori J.Sokoll, Jakub Stawicki, Stephen E.Stein, James Suh, Wojciech Szopa, Dave Tabor, Donghui Tan, Darlene Tansil, Ratna R.Thangudu, Cristina Tognon, Elie Traer, Shirley Tsang, Jeffrey Tyner, Ki SungUm, Dana R.Valley, Suhas Vasaikar, Negin Vatanian, Uma Velvulou, Michael Vernon, Weiqing Wan, Junmei Wang, Alex Webster, Bo Wen, Jeffrey R.Whiteaker, George D.Wilson, Yuriy Zakhartsev, Robert Zelt, Hui Zhang, Liwei Zhang, Zhen Zhang, Grace Zhao, Jun Zhu

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