Dysembryoplastic Neuroepithelial Tumor
Septal DNET generally presents with symptoms related to obstructive hydrocephalus.[69,70] Septal DNET has an indolent clinical behavior, with most tumors not requiring treatment other than surgery. In a single-institution series that incorporated other literature-reported cases, the median age at presentation was in the adolescent age range.
Mutations that are common in low-grade gliomas (e.g., BRAF V600E) and in cortical DNETs (FGFR1 mutations) are uncommon in septal DNET.[70-72] Instead, mutations in PDGFRA at the K385 residue typify most cases of septal DNET.
Available CBTN Biospecimens
participants with flash-frozen tissue available
participants with match blood
participants with match parental specimens
participants with cerebral spinal fluid
Available CBTN Pre-clinical Models
genomically characterized cell lines with data available
genomically characterized pdx with data available
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Exploring the Possible Role of Mutations in MTOR pathway Genes in the Pathogenesis of DNET tumors
Dysembryoplastic neuroepithelial tumors (DNET) genetic origins are little understood. Using samples from CBTN BioBank, researchers are conducting studies to help answer questions about their development to identify novel drug therapies.
Anna Maria Buccoliero