Ganglioglioma
Ganglioglioma
Summary of
Ganglioglioma
Ganglioglioma presents during childhood and into adulthood. It most commonly arises in the cerebral cortex and is associated with seizures, but also presents in other sites, including the spinal cord.[65,74]
The unifying theme for the molecular pathogenesis of ganglioglioma is genomic alterations leading to MAPK pathway activation.[42,75] BRAF alterations are observed in approximately 50% of ganglioglioma cases, with V600E being by far the most common alteration; however, other BRAF mutations and gene fusions are also observed. Other less commonly altered genes in ganglioglioma include KRAS, FGFR1/2, RAF1, NTRK2, and NF1.[42,75]
https://www.cancer.gov/types/brain/hp/child-astrocytoma-treament-pdq
Available CBTN Biospecimens
172participants with flash-frozen tissue available
82participants with match blood
14participants with match parental specimens
0participants with cerebral spinal fluid
Available CBTN Pre-clinical Models
1genomically characterized cell lines with data available
0genomically characterized pdx with data available
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