Nongerminomatous Germ Cell Tumors


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Summary of

Nongerminomatous Germ Cell Tumors

Primary CNS GCTs are a heterogeneous group of neoplasms that are more common in Japan and other Asian countries than in North America and Europe. In North America, they account for approximately 4% of all primary brain tumors, with a peak incidence from age 10 years to age 19 years and a male predominance in a pineal location.[1-3]

CNS GCTs are broadly classified as germinomatous and nongerminomatous germ cell tumors (NGGCTs) on the basis of clinicopathological and laboratory features, including tumor markers.[4,5] An alternative therapeutic classification in Japan distinguishes three groups on the basis of their prognostication: good prognosis (e.g., germinoma), intermediate prognosis (e.g., teratoma with malignant transformation), and poor prognosis (e.g., yolk sac tumor, choriocarcinoma, embryonal carcinoma, and mixed tumors of those entities).[4]

Source NCI

Available CBTN Biospecimens

participants with flash-frozen tissue available6

participants with flash-frozen tissue available

participants with match blood2

participants with match blood

participants with match parental specimens0

participants with match parental specimens

participants with cerebral spinal fluid1

participants with cerebral spinal fluid

Available CBTN Pre-clinical Models

genomically characterized cell lines with data available0

genomically characterized cell lines with data available

genomically characterized pdx with data available0

genomically characterized pdx with data available

How do I get access to the specimens?

To request any of the biospecimens, or pre-clinical model please fill out this form.
Request take approx. 3 months and will require review by the scientific committee and MTA.
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How do I get access to the data?

To access the data please follow these instructions. Need help? Contact us at
You can access processed data today here by simply logging in to PedcBioPortal
You can request raw data by completing this form. The review normally takes 1 week. Once approved you can access the raw data by creating cohorts of interest on the Kids First Data Resource Portal and performing analysis on the cloud in Cavatica