Alternative splicing of RNA is the process that changes information from genes into proteins that can be used by a cell. Alternative splicing plays a critical role in the regulation of gene expression and protein diversity found within a cell, and understanding its function across pediatric tumors could lead to the identification of new therapeutic targets.The long-term objective of this project is to use the data from the Pediatric Brain Tumor Atlas to study alternative splicing in pediatric brain tumor transcriptome. Researchers plan to use the comprehensive data provided by the Pediatric Brain Tumor Atlas to develop new computational and statistical methods for quantifying alternative splicing events in large datasets, propelling the search for new treatments forward.
What are the goals of this project?
Researchers plan to investigate the role of alternative splicing in the development of brain tumors and to develop new computational methods for future research of this kind.
What is the impact of this project?
This research into alternative splicing could lead to the identification of new therapeutic targets to be used in the treatment of pediatric brain cancers.
Why is the CBTN request important to this project?
The unique and comprehensive dataset available through the Pediatric Brain Tumor Atlas provides researchers with the information they need to complete this research.
The Children's Brain Tumor network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.