Brain Match

Current therapeutic approaches for pediatric central nervous system (CNS) tumors focus primarily on surgical removal and chemotherapy. Even in cases of successful treatment, cognitive and behavioral disabilities can arise. Hence, there is a pressing need to understand tumor genesis to devise better therapeutic strategies. Researchers aim to generate single cell level neurodevelopmental atlas for the human brain. Essentially, this means building an understanding of what happens as a tumor grows, cell by cell. This will serve as a map for researchers to better understand and determine the cell of origin for a range of CNS tumors. This information could be pivotal in making personalized treatment decisions. To make this research as comprehensive as possible, researchers will be accessing RNA data from the Pediatric Brain Tumor Atlas. The results from this study will enhance understanding of neurodevelopment and the timeline of pediatric brain cancer development, guiding treatment advances.