Current therapeutic approaches for pediatric central nervous system (CNS) tumors focus primarily on surgical removal and chemotherapy. Even in cases of successful treatment, cognitive and behavioral disabilities can arise. Hence, there is a pressing need to understand tumor genesis to devise better therapeutic strategies. Researchers aim to generate single cell level neurodevelopmental atlas for the human brain. Essentially, this means building an understanding of what happens as a tumor grows, cell by cell. This will serve as a map for researchers to better understand and determine the cell of origin for a range of CNS tumors. This information could be pivotal in making personalized treatment decisions. To make this research as comprehensive as possible, researchers will be accessing RNA data from the Pediatric Brain Tumor Atlas. The results from this study will enhance understanding of neurodevelopment and the timeline of pediatric brain cancer development, guiding treatment advances.
What are the goals of this project?
Researchers seek to build a map of cellular neurodevelopment in an effort to pinpoint the cells of origin for a range of brain cancers.
What is the impact of this project?
Through a detailed understanding of neurodevelopment of various CNS cancers, cell states prone to cancer development, and a timeline of tumor induction, researchers will open the door for the development of new targeted therapies.
Why is the CBTN request important to this project?
Access to the Pediatric Brain Tumor Atlas allows researchers to expand their work to include pediatric brain cancers.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas
Stefan M. Pfister, MD
Professor Dr. Stefan Pfister was appointed head of the Division Pediatric Neurooncology at the German Cancer Research Center. Professor Dr. Pfister´s research focuses on the genetic and epigenetic characterization of childhood brain tumors by applying nextgeneration profiling methods and subsequentl
Hopp Children's Cancer Center