Characterizing the Prevalence of ETMR by Molecular Signature

Embryonal tumors with multilayer rosettes (ETMR) are a rare and highly-aggressive tumor occurring in children. Historically, the tumor that is now defined as ETMR was considered to belong to a group of tumors known as CNS-PNET. As a group, CNS-PNETs were believed to represent approximately 3-7% of all pediatric brain tumor cases, however ETMR is extremely rare with less than 300 cases reported in medical literature. Due to its rarity and recent reclassification, clinical investigations of this tumor are still evolving and the incidence and prevalence of ETMR is unknown. Using specimen data from the Pediatric Brain Tumor Atlas, researchers aim to understand the prevalence of ETMR, informing future studies into the tumor.