Comprehensive analysis of structural variants in pediatric brain tumors

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CBTN Data Used


R03 grant

About this


Structural variations (SVs) are large scale changes of DNA typically affecting more nucleotides than other forms of genetic variants. We aim to study how somatic SVs are formed, how they drive disease progression and how they impact treatment in pediatric brain tumors.

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What are the goals of this project?

The goals of this project are to study the forming mechanisms of somatic structural variants (SVs), identify new disease causing variants and associate somatic variants with treatment outcome

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.