Structural variations (SVs) are large scale changes of DNA typically affecting more nucleotides than other forms of genetic variants. We aim to study how somatic SVs are formed, how they drive disease progression and how they impact treatment in pediatric brain tumors.
What are the goals of this project?
The goals of this project are to study the forming mechanisms of somatic structural variants (SVs), identify new disease causing variants and associate somatic variants with treatment outcome
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.