Detection of Cooperative and Mutually Exclusive Genetic Alterations in Pediatric Cancer

Email Principal Investigator
All Brain Tumor Types
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Patrick Kemmeren

Princess Maxima Center for Pediatric Oncology
Utrecht, Netherlands, Amsterdam



CBTN Participants


Dutch Cancer Foundation

About this


Changes that occur in genes are called genetic alterations. Understanding the genetic interactions of pediatric brain cancers and how they are altered in the genomes of patients could lead to better diagnostics, therapies, and ongoing assessments. Researchers will use data from the Pediatric Brain Tumor Atlas to test genetic interactions in individual cancer types and broadly across all cancer types. This research will create a broad dataset that will be invaluable in the continued pursuit of new treatment techniques and therapies.

Ask The


Ask the scientists

What are the goals of this project?

Researchers seek to develop and analyze a broad set of data on the genetic alterations of many types of pediatric brain tumors.

What is the impact of this project?

This research will study a broad set of pediatric brain cancers, contributing greatly to the body of genetic information necessary to develop new therapeutics.

Why is the CBTN request important to this project?

The Pediatric Brain Tumor Atlas contains specimens across all pediatric brain tumor types, contributing to the broad impact of this project.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals


Meet The



Patrick Kemmeren, PhD

The Kemmeren group uses bioinformatics and systems biology to understand the molecular mechanisms underlying genetic interactions in relation to cellular processes and childhood cancer types. We have developed a unique combination of expertise in bioinformatics, gene expression profiling and molecul

Princess Maxima Center for Pediatric Oncology.jpg

Princess Maxima Center for Pediatric Oncology

Utrecht, Netherlands, Amsterdam

Josephine Daub, PhD

Cancer develops through the acquisition of multiple mutations, and it is assumed that genetic interactions between mutated genes play an important role in cancer onset and progression. One approach to find genetic interactions in cancer is to search for pairs of mutated genes in tumors that occur to

Princess Maxima Center for Pediatric Oncology.jpg

Princess Maxima Center for Pediatric Oncology

Utrecht, Netherlands, Amsterdam

Stefan M. Pfister, MD

Professor Dr. Stefan Pfister was appointed head of the Division Pediatric Neurooncology at the German Cancer Research Center. Professor Dr. Pfister´s research focuses on the genetic and epigenetic characterization of childhood brain tumors by applying nextgeneration profiling methods and subsequentl


Hopp Children's Cancer Center

Heidelberg, Germany

Jinghui Zhang, PhD

My research interest has been in the development of highly accurate and sensitive computational methods for analyzing large-scale genomic data, especially in the area of detecting and analyzing genetic variations and somatic mutations. My group has developed computational tools for analyzing genetic


St. Jude Children's Research Hospital

262 Danny Thomas Place, Memphis, TN 38105