CBTN Data
About this
Project
Chordoma is a malignant, often incurable bone tumour of the spine in adults and children. The principal treatment of chordoma is surgery, and radiation therapy, but success is minimal. Researchers hope to identify mutations that drive the growth of Chordoma tumors in pediatric and adult patients. The goal of this project is to describe the landscape of driver mutations and mutational processes in sporadic chordoma, including paediatric chordoma, and investigate their relationship with clinical characteristics. Once mutations that drive the development of chordoma tumors are identified researchers can begin the development of improved therapies. Without access to the Pediatric Brain Tumor Atlas, researchers would be unable to carry out these comparisons.
Ask The
Scientists
What are the goals of this project?
The goals of this project are to describe the landscape of driver mutations and mutational processes in sporadic chordoma and to investigate their relationship to clinical outcomes.
What is the impact of this project?
Once driver mutations are identified, they can be further investigated for their use in the development of new therapies for patients with chordoma.
Why is the CBTN request important to this project?
Without access to the Pediatric Brain Tumor Atlas, researchers would be unable to carry out comparisons of these tumors.
Specimen Data
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.