The association between germline genetic variants and risk of developing a brain tumor in childhood will be investigated using statistical analysis including cases of brain tumors (CBTTC/PNOC data) and control subjects. Analyses will be done separately for different subtypes of tumors. Results will be combined with results from other studies using meta-analysis. We will also use CBTTC/PNOC data to investigate how genetic variants are related to molecular characteristics in the tumor, for example somatic alterations, gene expression, and DNA methylation.
What are the goals of this project?
To investigate the association between germline genetic variants and risk of developing a brain tumor in childhood.
To investigate how genetic variants are related to gene regulation and tumor phenotype.
What is the impact of this project?
Understanding how germline genetic variants contribute to the risk of developing brain tumors will help us to understand the etiology of the disease.
Why is the CBTN request important to this project?
World-wide collaboration is necessary to study childhood brain tumors, which are both clinically and molecularly diverse.