Molecular and functional characterization of childhood supratentorial ependymoma

I am requesting CBTTC specimens as this provides an opportunity to validate my current findings in a large validation cohort comprising high quality tumor tissue, which comprises patients treated on modern protocols. Considering the rarity of supratentorial ependymoma and the overall difficulties in obtaining the current discovery cohort, this provides an opportunity to validate both the non-canonical fusion incidence in a sufficiently large cohort with frozen tissue amenable to both RNA sequencing and DNA methylation. The available of tissue from institutions treating with standard protocols will also allow for clinical interpretation of these non-canonical fusions. The other specimens currently used are from the Hospital for Sick Children, and several eastern European and Asian institutions, none of which are members of the CBTTC.