Pediatric Pan-Cancer Analysis of Structural VariantsEmail Principal Investigator
Dragon Masters Foundation
Researchers have previously performed a comprehensive analysis of 961 tumours from children, adolescents, and young adults, comprising 24 distinct molecular types of cancer. That project also identified marked differences in terms of mutation frequency and significantly mutated genes in pediatric cancers in comparison to adult cancers. Identification of these differences allows for the classification of tumors, an important step in diagnosis and treatment. A deeper understanding of cancer classification leads to more accurate and effective treatments. For this project, researchers have now developed new and improved tools for the analysis of whole genome sequencing data, information about each gene in a genome. They will perform a similar analysis across pediatric cancer types focused on the discovery of genomic rearrangements using their new tools. Data about gene expression will be integrated into the analysis, furthering researcher’s efforts to bolster classification. The Pediatric Brain Tumor Atlas will provide researchers with the data necessary to focus this work on the pediatric brain cancer population.
What are the goals of this project?
Researchers will investigate mutations across pediatric brain tumors using newly developed tools in an effort to strengthen tumor classification, which is a vital part of making appropriate treatment decisions.
What is the impact of this project?
Tumor classification is an important piece of cancer diagnosis because different tumors, tumor subtypes, and particular mutations require different modes of treatment. This project will strengthen tumor classification for pediatric brain tumors.
Why is the CBTN request important to this project?
Similar work has been carried out on a range of age groups and access to the Pediatric Brain Tumor Atlas will provide researchers with the data necessary to focus this work on the pediatric brain cancer population.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.