We are requesting models of childhood ependymoma (both supratentorial and posterior fossa) which propagate in vitro, which are amenable to both chemical and genetic screening. As there is a paucity of ependymoma models that propagate in vitro, these will be extremely valuable to identify potential therapeutic targets which can be developed further.
Currently we have generated three models which can be passaged in short-term culture and have obtained EP1NS from the DKFZ, 210FH from the BTRL and 1425TX from baylor college of medicine.
