Project Hope: High-Grade Glioma-Omics in Pediatric and AYA

High grade gliomas affect patients across age groups, and this project seeks to better understand high grade gliomas as they affect pediatric, adolescent, and young adult populations. The goal of this project is to generate single cell sequencing data of cancer cells, immune cells and non-immune microenvironment in pediatric and adolescent and young adult high-grade gliomas. Researchers hypothesize that combining analysis of single-cell techniques, the microenvironment, and the immune factors of tumors and matched preclinical models will lead to a better understanding of these diseases. Deeper understanding will then promote the development of more effective therapeutics to improve outcomes for patients. The Children’s Brain Tumor Network provides a unique resource of samples and data necessary for this project.