Dogs with spontaneous cancers have been considered useful preclinical models in the development of treatment strategies for human cancers in addition to new therapies for dogs. Through the comparison of genetics of spontaneous tumors across species, researchers can identify shared structural variants (SVs) in the genome that could lead to advancements in treatment. There are several active translational canine trial efforts involving some specific tumor types supported by the National Cancer Institute Cancer Moonshot project and other initiatives facilitating collection efforts. This research group has been studying canine cancer genomics and developing resources for such comparative cancer research. Additionally, the comparative genomic analyses have identified that canine cancers included various SVs that are conserved in human counterparts. This has led to increased efforts in the comparative analysis of sequencing data across species, providing novel findings and leading to utilization of canine cancers as models. Researchers will leverage their expertise in analyzing structural variants in human and canine cancer datasets to expand their study with data provided through the Pediatric Brain Tumor Atlas.
What are the goals of this project?
Researchers will complete cross-species comparative analysis for dog and human cancers.
What is the impact of this project?
Dogs with cancers have been considered useful models for use in developing treatments for human and canine cancers, and this work will expand upon this analysis in the hopes of increasing the usefulness of such models.
Why is the CBTN request important to this project?
The Pediatric Brain Tumor Atlas provides researchers with comprehensive data sets on pediatric brain cancers that will be integral for this comparative analysis.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas