We hypothesize that macrophages within pediatric brain tumors (PBT) may enable local tumor regrowth and spinal metastasis. To determine the burden of infiltrating macrophage in human PBT tissue samples, we plan to correlate gene expression of macrophage signature genes with patterns of clinical progression and outcome
What are the goals of this project?
The goals of this project are to describe the prevalence of tumor-associated macrophage (TAM) burden in pediatric brain tumors and explore associations with clinical outcomes and to investigate potential correlations of the CSF-1 paracrine loop with the development of spinal metastases in pediatric brain tumors
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.