Targeting Immunosuppressive Macrophage in Pediatric Brain Tumors
Macrophages are specialized immune cells involved in the detection and destruction of bacteria and other harmful organisms in the body. Tumor-associated macrophages (TAM) are immune cells found in solid tumors and these macrophages are believed to contribute to the growth and expansion of tumors including metastasis into the spinal cord. Therefore, TAMs represent possible targets in the treatment of pediatric brain cancers. Researchers seek to analyze data provided through the Pediatric Brain Tumor Atlas to understand the prevalence of TAMs in various cancer types. Through comparison of this data with patterns of cancer progression, researchers hope to identify new targets for the application of therapies.
What are the goals of this project?
Researchers seek to find patterns in cancer progression associated with TAMs, which could be used as new therapeutic targets in the treatment of pediatric brain cancer.
What is the impact of this project?
New therapies are needed in the treatment of pediatric brain cancers, especially in patients who experience tumor regrowth. The identification of TAM targets could open the door to new therapies.
Why is the CBTN request important to this project?
Through access to the Pediatric Brain Tumor Atlas, researchers will be able to identify the impact of TAMs across pediatric brain cancers.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.