The Role of Histone Chaperones in H3.3K27M-altered Pediatric Diffuse Midline Glioma

Diffuse midline glioma (DMG) is a highly aggressive and lethal brain tumor that occurs in young children between 6-9 years old. The overall survival of children with DMG is only 9-15 months with no curative therapies to date. Our proposed study will establish the identity of H3.3K27M histone chaperone, uncover its role in tumorigenesis and provide the mechanistic rationale for therapeutically targeting the oncohistone chaperone as a novel treatment strategy for children with currently incurable H3K27M DMG.