CBTN

The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science

Published in
Neoplasia
on
Jena V. Lilly, Jo Lynne Rokita, Jennifer L. Mason, Tatiana Patton, Stephanie Stefankiewiz, David Higgins, Gerri Trooskin, Carina A. Larouci, Kamnaa Arya, Elizabeth Appert, Allison P. Heath, Yuankun Zhu, Miguel A. Brown, Bo Zhang, Bailey K. Farrow, Shannon Robins, Allison M. Morgan, Thinh Q. Nguyen, Elizabeth Frenkel, Kaitlin Lehmann, Emily Drake, Catherine Sullivan, Alexa Plisiewicz, Noel Coleman, Luke Patterson, Mateusz Koptyra, Zeinab Helili, Nicholas Van Kuren, Nathan Young, Meen Chul Kim, Christopher Friedman, Alex Lubneuski, Christopher Blackden, Marti Williams, Valerie Baubet, Lamiya Tauhid, Jamie Galanaugh, Katie Boucher, Heba Ijaz, Kristina A. Cole, Namrata Choudhari, Mariarita Santi, Robert W. Moulder, Jonathan Waller, Whitney Rife, Sharon J. Diskin, Marion Mateos, Donald W. Parsons, Ian F. Pollack, Stewart Goldman, Sarah Leary, Chiara Caporalini, Anna Maria Buccoliero, Mirko Scagnet, David Haussler, Derek Hanson, Ron Firestein, Jason Cain, Joanna J. Phillips, Nalin Gupta, Sabine Mueller, Gerald Grant, Michelle Monje-Deisseroth, Sonia Partap, Jeffrey P. Greenfield, Rintaro Hashizume, Amy Smith, Shida Zhu, James M. Johnston, Jason R. Fangusaro, Matthew Miller, Matthew D. Wood, Sharon Gardner, Claire L. Carter, Laura M. Prolo, Jared Pisapia, Katherine Pehlivan, Andrea Franson, Toba Niazi, Josh Rubin, Mohamed Abdelbaki, David S. Ziegler, Holly B. Lindsay, Ana Guerreiro Stucklin, Nicolas Gerber, Olena M. Vaske, Carolyn Quinsey, Brian R. Rood, Javad Nazarian, Eric Raabe, Eric M. Jackson, Stacie Stapleton, Robert M. Lober, David E. Kram, Carl Koschmann, Phillip B. Storm, Rishi R. Lulla, Michael Prados, Adam C. Resnick, Angela J. Waanders
CBTN Landscape Paper
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Abstract

Pediatric brain tumors are a leading cause of cancer-related deaths in children in the United States, and survivors often suffer long-term side effects. The Children's Brain Tumor Network (CBTN) is a group of 32 institutions working together to collect and distribute biospecimens and data for pediatric brain tumors through open-science research platforms. As of August 2022, CBTN has enrolled over 4700 subjects and collected over 65,000 biospecimen aliquots. They have developed over 80 preclinical models from collected tumors and have multi-omic data for over 1000 tumors and germline material. CBTN provides the largest open-access pediatric brain tumor multi-omic dataset with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. The CBTN is supported by NIH platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, which will help scientists accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors.

Acknowledgements

We would like to thank the patients and families participating in CBTN. CBTN is in large part, philanthropically-funded, and we thank each donor for their dedication and support in making the CBTN possible. The following donors have provided leadership level support: Children's Brain Tumor Foundation, Eaise Family Foundation, Kortney Rose Foundation, Lilabean Foundation, Minnick Family Charitable Fund, Perricelli Family, Psalm 103 Foundation, and Swifty Foundation. CBTN's leadership would like to recognize and thank the early leadership and foundational contributions of Drs. Tom Curran, Ph.D., FRS (currently at Children's Mercy Kansas City) and Peter Phillips, M.D. (formerly at CHOP, retired) to the creation of Children's Brain Tumor Tissue Consortium (CBTTC) which has evolved into the Children's Brain Tumor Network (CBTN).