Circular and Fusion RNAs in Medulloblastoma Development

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Ani Azatyan, Peter G. Zaphiropoulos *


Medulloblastoma is the most common pediatric brain cancer. Using RNA sequencing data from CBTN, researchers on this project detect circular and fusion RNAs within medulloblastoma. Their observations show that the formation of fusion transcripts may be taking place at both the chromosomal and RNA level. They also identified deregulated circular RNA found in the four subtypes of medulloblastoma. Understanding the molecular details of such tumors allow researchers and clinicians to accelerate discovery of treatments.