Global Molecular Alterations Involving Recurrence or Progression of Pediatric Brain Tumors

Published in
Fengju Chen, Darshan S. Chandrashekar, Michael E. Scheurer, Sooryanarayana Varambally, Chad J. Creighton
Global molecular alterations involving recurrence or progression of pediatric brain tumors


We aimed to identify molecular changes in recurrent or progressive pediatric brain tumors, as compared to the corresponding initial tumors from the same patients, using genomic, transcriptomic, and proteomic data from a unique and large cohort of 55 patients and 63 recurrent or progressive tumors from the Children’s Brain Tumor Tissue Consortium, representing various histologic types.