Interactions Between Immune Microenvironment, Stem Cells, and Cell Proliferation in Pediatric Embryonal Central Nervous System Cancers

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Kristian Schafernak, Emma Utagawa, Shwetal Mehta, Tiffany Di Modica, Elliott Mufson, and Sylvia Perez
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Mounting evidence suggests the brain’s own immune cells, microglia, and perivascular macrophages play important roles in immune surveillance/inflammation, but also support proliferation/growth of gliomas, possibly through interactions with tumor stem cells. Immune cells are increasingly regarded as potential targets for cancer therapy, however, the immune microenvironment has not been well-studied in pediatric embryonal CNS tumors.