Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs
Bongyong Lee, Iqbal Mahmud, Rudramani Pokhrel, Rabi Murad, Menglang Yuan, Stacie Stapleton, Chetan Bettegowda, George Jallo, Charles G. Eberhart, Timothy Garrett & Ranjan J. Perera
Abstract
Medulloblastoma (MB) is the most common malignant brain tumor in children, however there is a great need for sensitive diagnostic tools. Diagnostic tools that use cerebrospinal fluid (CSF) present an opportunity for advancement. This study identifies signatures within CSF that are promising pending further validation. Once validated these could be used to help to detect tumors early and are very important for tracking tumor recurrences.