Pro-inflammatory Cytokines Mediate the Epithelial-to-Mesenchymal-like Transition of Pediatric Posterior Fossa Ependymoma
Rachael G. Aubin, Emma C. Troisi, Javier Montelongo, Adam N. Alghalith, Maclean P. Nasrallah, Mariarita Santi, Pablo G. Camara
Abstract
Pediatric ependymoma is a brain tumor known for its pattern of recurrence. Unfortunately, there is a lack of effective chemotherapies targeting ependymoma due to a limited knowledge of how the tumor forms and grows. This shortage of treatments is due to limited knowledge about how ependymoma tumors develop and grow. . In this study, researchers reveal key drivers in the differentiation of ependymoma tumor cells. They identify NFκB, AP-1, and MYC as mediators of this cell transition.