Proteogenomic Characterization of 2002 Human Cancers Reveals Pan-Cancer Molecular Subtypes and Associated Pathways

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Yiqun Zhang, Fengju Chen, Darshan S. Chandrashekar, Sooryanarayana Varambally, Chad J. Creighton


With the inclusion of RNA sequencing data provided by CBTN, researchers assembled a dataset of over 2000 tumors across 14 cancer types. Using this dataset, the research team identified 11 distinct tumor types, including 2 subtypes enriched for brain tumors. This pan-cancer survey reveals interplay between the genome and proteome of cancer types found throughout the body and deepens the overall understanding of how brain tumors develop and grow.