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Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor

Published in
Neoplasia
on
Elizabeth Alva, Jeffrey Rubens, Susan Chi, Tom Rosenberg, Alyssa Reddy, Eric H. Raabe, Ashley Margol
ATRT Progress
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Abstract

Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) tumors that occur mostly in young children and have historically carried a very poor prognosis. While recent clinical trial results show that this tumor is curable, outcomes are still poor compared to other central nervous system embryonal tumors. We here review prior AT/RT clinical trials and highlight promising pre-clinical results that may inform novel clinical approaches to this aggressive cancer.