Pediatric intracranial ependymoma, a type of brain tumor, has recently been divided into subgroups based on specific characteristics. This new information can make it more difficult to draw conclusions from past treatments, but it also presents an opportunity to better understand the disease and develop effective therapies. This publication reviews some of the most important clinical questions that need to be addressed in order to improve patient care and design future clinical trials. Researchers also explore the challenges that must be overcome to translate preclinical research into effective treatments for children with ependymoma. Overall, this work highlights the need for ongoing research and collaboration among healthcare professionals to improve outcomes for pediatric brain tumor patients.