Clinical Research Associate
Center for Data Driven Discovery in Biomedicine
Namrata Choudhari is a Clinical Research Associate responsible for supporting medical diagnostic and pre-clinical research efforts. She also builds pipelines for research testing and mRNA-based modification and cell delivery in the development of novel immunotherapies. Her research is focused primarily on immunotherapy, molecular profiling and the discovery of pediatric brain tumor bio-markers.
Namrata joined CHOP in October of 2009. She is committed to discovering a new mRNA-based approach to improve CAR T cells immunotherapies against tumor cells.
Children’s Hospital of Philadelphia
Human Gene Therapy
Purification of mRNA Encoding Chimeric Antigen Receptor is Critical for Generation of Robust T-Cell Response
T cells made with messenger RNA (mRNA) encoding chimeric antigen receptor (CAR) offer a safe alternative to those transduced with viral CARs by mitigating the side effects of constitutively active T cells. Previous studies have shown that mRNA CAR T cells are transiently effective but lack persisten
Jessica B Foster, Namrata Choudhari, Jessica Perazzelli, Julie Storm, Ted J Hofmann, Payal Jain, Phillip Storm, Norbert Pardi, Drew Weissman, Angela J Waanders, Stephan A Grupp, Katalin Karikó, Adam C Resnick, PhD, David M Barrett