NIH Distinguished Investigator

National Institute of Health

My group studies DNA recombination, repair, and replication. In particular, we are interested in V(D)J recombination, mismatch repair, nucleotide excision repair, and translesion DNA synthesis. We use X-ray crystallography, cryoEM, molecular biology, and various biochemical and biophysical approaches to find out the molecular mechanisms underpinning these biological processes. In recent years, we have discovered that DNA synthesis and RNA degradation reactions are propelled by cation trafficking and require transiently bound Mg²⁺ and K⁺ ions that are absent in the static structures of substrate- or product-enzyme complexes.