Childhood craniopharyngiomas are rare tumors usually found near the pituitary gland (a pea-sized organ at the bottom of the brain that controls other glands) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves).
Craniopharyngiomas are usually part solid mass and part fluid -filled cyst. They are benign (not cancer) and do not spread to other parts of the brain or to other parts of the body. However, they may grow and press on nearby parts of the brain or other areas, including the pituitary gland, the optic chiasm, optic nerves, and fluid-filled spaces in the brain. Craniopharyngiomas may affect many functions of the brain. They may affect hormone making, growth, and vision. Benign brain tumors need treatment. Who 2016 classification Tumors of sellar region.
How many participants are enrolled?
Available CBTN Biospecimens
participants with flash-frozen tissue available
participants with match blood
participants with match parental specimens
participants with cerebral spinal fluid
Available CBTN Pre-clinical Models
genomically characterized cell lines with data available
genomically characterized pdx with data available
Projects supported by the CBTN
Data projects supported
Specimen projects supported
What type of data are available?
Investigating Disease Mechanism In Adamantinomatous Craniopharyngioma Using New Cell Line Models
Adamantiomatious Craniopharyngioma (ACP) is a benign intracranial tumor that is thought to arise from embryonic remnants of Rathke’s pouch. Though histologically benign, the clinical manifestation of the disease is profound due to the location of the tumor in the sellar/parasellar region around c
How do I get access to the specimens?
To request any of the biospecimens, or pre-clinical model please fill out this form.
Request take approx. 3 months and will require review by the scientific committee and MTA.
Need help? Contact us at firstname.lastname@example.org
How do I get access to the data?
To access the data please follow these instructions. Need help? Contact us at email@example.com
You can access processed data today here by simply logging in to PedcBioPortal
You can request raw data by completing this form. The review normally takes 1 week. Once approved you can access the raw data by creating cohorts of interest on the Kids First Data Resource Portal and performing analysis on the cloud in Cavatica
Flash frozen tissue is tissue from a surgical procedure where the tissue is frozen instantly in liquid nitrogen to ensure there is no degradation
Tissue in freezing media is tissue from a surgical procedure where the tissue is frozen 1 degree at a time over a 24-hour period to keep the tissue intact and compatible with regrowing the tumor for testing
Matched blood is blood that is collected from the patient in addition to tissue from the tumor. This blood provides researchers a direct comparison between normal and tumor specimens for this specific patient
Cerebral Spinal Fluid (CFS) is fluid taken from the the nervous system that researchers can use to study brain tumors
Paternal and maternal specimens are specimens taken from the biological parents of the subject. These specimens provide researchers with the ability to compare tumor and normal tissue and predispositions