Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumors that arise in or around the fourth ventricle. The 2016 WHO classifcation indicated one genetically defined ependymoma subtype has been accepted: Ependymoma, RELA fusion–positive [33, 36]. This variant accounts for the majority of supratentorial tumors in children. (Louis DN, 2019)
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Molecular and Functional Characterization of Childhood Supratentorial Ependymoma
There are many established subtypes of pediatric ependymoma and they may require different modes of treatment. Using samples and data provided by the Children’s Brain Tumor Atlas, researchers seek to better understand these differences in an effort to direct personalized care.
Cell Ecosystem and Signaling Pathways of Primary and Metastatic Pediatric Posterior Fossa Ependymoma
Ependymomas constitute nearly one third of the central nervous system neoplasms among children aged < 3 years1. The disease remains a significant therapeutic challenge, with a 5-year overall survival rate < 55 % among this age group2 and no available chemotherapy of proven efficacy. The breadth of t
Pablo G. Cámara