Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumors that arise in or around the fourth ventricle. The 2016 WHO classifcation indicated one genetically defined ependymoma subtype has been accepted: Ependymoma, RELA fusion–positive [33, 36]. This variant accounts for the majority of supratentorial tumors in children. (Louis DN, 2019)
How many participants are enrolled?
Available CBTN Biospecimens
participants with flash-frozen tissue available
participants with match blood
participants with match parental specimens
participants with cerebral spinal fluid
Available CBTN Pre-clinical Models
genomically characterized cell lines with data available
genomically characterized pdx with data available
Projects supported by the CBTN
Data projects supported
Specimen projects supported
What type of data are available?
Personalized Therapy For High-risk Ependymoma Of Childhood
Ependymoma is the third most common brain tumour of childhood, and current treatments are limited to surgery and radiation even in very young children. Both supratentorial and posterior fossa ependymoma are relatively chemotherapy resistant, and patients with relapsed or subtotally resected dise
Molecular and Functional Characterization of Childhood Supratentorial Ependymoma
Ependymoma is the third most common brain tumor of childhood, and can occur anywhere in the nervous system. Although classically described as a single entity, it is now very clear that different compartments of ependymoma are totally different diseases, specifically the supratentorial, posterior
Cell Ecosystem and Signaling Pathways of Primary and Metastatic Pediatric Posterior Fossa Ependymoma
Ependymomas constitute nearly one third of the central nervous system neoplasms among children aged < 3 years1. The disease remains a significant therapeutic challenge, with a 5-year overall survival rate < 55 % among this age group2 and no available chemotherapy of proven efficacy. The bre
Pablo G. Cámara
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You can request raw data by completing this form. The review normally takes 1 week. Once approved you can access the raw data by creating cohorts of interest on the Kids First Data Resource Portal and performing analysis on the cloud in Cavatica
Flash frozen tissue is tissue from a surgical procedure where the tissue is frozen instantly in liquid nitrogen to ensure there is no degradation
Tissue in freezing media is tissue from a surgical procedure where the tissue is frozen 1 degree at a time over a 24-hour period to keep the tissue intact and compatible with regrowing the tumor for testing
Matched blood is blood that is collected from the patient in addition to tissue from the tumor. This blood provides researchers a direct comparison between normal and tumor specimens for this specific patient
Cerebral Spinal Fluid (CFS) is fluid taken from the the nervous system that researchers can use to study brain tumors
Paternal and maternal specimens are specimens taken from the biological parents of the subject. These specimens provide researchers with the ability to compare tumor and normal tissue and predispositions