Gliomatosis cerebri is a primary central nervous system (CNS) tumor. This means it begins in the brain or spinal cord. This tumor is no longer recognized as a formal diagnosis, rather gliomatosis cerebri refers to a special pattern of diffuse and extensive growth of glioma cells, invading multiple lobes of the brain. Gliomas of different grade and cell of origin (astrocytes, oligodendrocytes) can grow with this pattern, and very little is understood about the molecular basis of the disease. More research is needed to discover the origin of these tumors and to improve their treatment.
(Source: National Cancer Institute)
Available CBTN Biospecimens
participants with flash-frozen tissue available
participants with match blood
participants with match parental specimens
participants with cerebral spinal fluid
Available CBTN Pre-clinical Models
genomically characterized cell lines with data available
genomically characterized pdx with data available
Explore the data in these informatics portals
Kids First Data Resource Portal
Kids First Portal is a search tool which allows users to explore the full availability of CBTN data and build cohorts of participants and files for further study.
The following data are available:
Whole Genome Sequencing
Tissue Slide Images
How do I get access to the data?
To access the data please follow these instructions. Need help? Contact us at firstname.lastname@example.org
You can access processed data today here by simply logging in to PedcBioPortal
You can request raw data by completing this form. The review normally takes 1 week. Once approved you can access the raw data by creating cohorts of interest on the Kids First Data Resource Portal and performing analysis on the cloud in Cavatica
Activation of Invasion and Metastasis
Spatial Evolution and Somatic Mutations Spectrum of Gliomatosis Cerebri
The development of treatment for Gliomatosis cerebri and other high grade gliomas relies on a comprehensive understanding of each tumor type. Using the Pediatric Brain Tumor Atlas alongside other open access datasets, researchers will map and analyze how tumors change over time, across locations, and the specific proteins created in Gliomatosis cerebri.