Spatial evolution and somatic mutations spectrum of Gliomatosis Cerebri

Email Principal Investigator

Gliomatosis Cerebri tumors

About this


The goal of this project is to do an analysis of the spatial evolution and genetic-epigenetic landscape in Gliomatosis Cerebri and other HGG. To do this, the team will use innovative tools in computational biology to map the spatial differences in glioma progression.

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What are the goals of this project?

The goals of this project are to characterize the genome and epigenome of Gliomatosis Cerebri tumor and to utilize open-access datasets to investigate other pediatric CNS tumors (DIPG, Ependymoma)

Why the CBTN request is important to this project?

The CAVATICA platform contains whole exome sequencing, whole genome sequencing, RNA-seq, genotyping array, miRNA-seq, and methylation arrays, in addition to corresponding relevant, clinical data. We plan to expand our existing datasets and compare the genomic data from CAVATICA to our existing dataset.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

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