The treatment of gliomatosis cerebri and other high grade gliomas (HGG) such as diffuse intrinsic pontine gliomas (DIPG) and ependymoma relies on a comprehensive understanding of each tumor type. Utilizing advancements in computational biology, researchers will use the Pediatric Brain Tumor Atlas and other open access datasets to map the characteristics, growth, progression, metastasis of gliomatosis cerebri and various HGG. This information will deepen the understanding of HGG, guiding tumor assessment, treatment decisions and therapeutic developments.
What are the goals of this project?
Using advances in computational biology, researchers seek to better understand the genetic underpinnings of various HGG including gliomatosis cerebri and DIPG.
What is the impact of this project?
By mapping the differences in the progression of various tumor types, researchers are building a knowledge base that will be helpful in guiding the decisions of medical professionals and to propel the discovery of new therapies.
Why is the CBTN request important to this project?
The Pediatric Brain Tumor Atlas will be used to expand the datasets necessary to complete this project.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Jeffrey Greenfield, MD, PhD
Dr. Greenfield’s directs multiple research projects pertaining to pediatric brain tumors, in particular, basic research examining the brain tumor microenvironment, tumor immunology, and precision medicine. This research has been externally funded and widely published and he has received national awa
Weill Cornell Medicine
Weill Cornell MedicineJoined on
The Weill Cornell Medicine Pediatric Brain and Spine Center, located on the Upper East Side campus of New York-Presbyterian/Weill Cornell Medical Center, is nationally recognized for its leadership in the treatment of disorders of the central nervous system in children, particularly brain and spinal
Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumors
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with