The goal of this project is to do an analysis of the spatial evolution and genetic-epigenetic landscape in Gliomatosis Cerebri and other HGG. To do this, the team will use innovative tools in computational biology to map the spatial differences in glioma progression.
What are the goals of this project?
The goals of this project are to characterize the genome and epigenome of Gliomatosis Cerebri tumor and to utilize open-access datasets to investigate other pediatric CNS tumors (DIPG, Ependymoma)
Why the CBTN request is important to this project?
The CAVATICA platform contains whole exome sequencing, whole genome sequencing, RNA-seq, genotyping array, miRNA-seq, and methylation arrays, in addition to corresponding relevant, clinical data. We plan to expand our existing datasets and compare the genomic data from CAVATICA to our existing dataset.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
- Mark Souweidane, MD
Jeffrey Greenfield, MD, PhD
Dr. Greenfield’s directs multiple research projects pertaining to pediatric brain tumors, in particular, basic research examining the brain tumor microenvironment, tumor immunology, and precision medicine. This research has been externally funded and widely published and he has received national
Weill Cornell Medicine Pediatric Brain & Spine Center
Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumo
Brainstem glioma- Diffuse intrinsic pontine glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor.[