Vice Chairman for Academic Affairs and Associate Residency Director; Associate Professor of Neurological Surgery and Pediatrics, Department of Neurological Surgery
Weill Cornell Medicine Pediatric Brain & Spine Center
Dr. Greenfield’s directs multiple research projects pertaining to pediatric brain tumors, in particular, basic research examining the brain tumor microenvironment, tumor immunology, and precision medicine. This research has been externally funded and widely published and he has received national awards from neurosurgical societies. He has lectured internationally on these subjects and together with Dr. Mark Souweidane he co-directs the Children’s Brain Tumor Project, focusing on novel approaches and innovative care for children with rare and inoperable brain tumors.
Epigenetic Basis of Gender Differences in Pediatric GBM
CBTN specimen will be used for reduced representation bisulfite sequencing - we will be profiling the transcriptome and epigenome. We will then compare these profiles between boys and girls with pediatric GBM to identify lesions that cause the difference in clinical outcomes of these patients.
Searching for Differences in Molecular Profile of Pediatric Gliomas
Childhood brain cancer is a devastating disease that is still poorly understood. Glioma is a type of brain cancer in which a specific type of cells in the brain (called glial cells), become cancerous. In our study, we will examine how the DNA in glioma cells varies between different groups of pat
Relationships Between Genomic, Imaging, and Histopathologic Characteristics in Pediatric Brain Tumors
We wish to analyze genetic sequences of samples of different families of pediatric brain tumors, and thereafter perform machine learning-based natural language processing algorithms on text-based clinical data from the same specimens.
Spatial evolution and somatic mutations spectrum of Gliomatosis Cerebri
The goal of this project is to do an analysis of the spatial evolution and genetic-epigenetic landscape in Gliomatosis Cerebri and other HGG. To do this, the team will use innovative tools in computational biology to map the spatial differences in glioma progression.
Childhood craniopharyngiomas are rare tumors usually found near the pituitary gland (a pea-sized organ at the bottom of the brain that controls other glands) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves).Craniopharyngiomas are usually part soli
Medulloblastomas comprise the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinica
High-grade glioma/astrocytoma (WHO grade III/IV)
High-grade Gliomas (HGG) in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric specific HGG preclinical models. These models are needed to help test the effective
Brainstem glioma- Diffuse intrinsic pontine glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor.[