High-Grade Glioma


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enrolled participants

Data Projects Supported
Specimen Projects Supported
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Summary of

High-Grade Glioma

High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test the effectiveness of different drug types in the laboratory. Medical advances over the last 40 years have increased the survival rates for many types of childhood cancers. However, the prognosis for patients diagnosed with a Diffuse Intrinsic Pontine Glioma (DIPG) has not improved. These highly-aggressive brain tumors defy treatment and have a 98% mortality rate,typically within nine months of a diagnosis. Located in the area of the brainstem that controls a child’s breathing, blood pressure, heart rate, and other vital functions, DIPG tumors cannot be removed through surgery. WHO 2016 Classification Diffuse astrocytic and oligodendroglial tumor.

Available CBTN Biospecimens

participants with flash-frozen tissue available329

participants with flash-frozen tissue available

participants with match blood168

participants with match blood

participants with match parental specimens25

participants with match parental specimens

participants with cerebral spinal fluid29

participants with cerebral spinal fluid

Available CBTN Pre-clinical Models

genomically characterized cell lines with data available38

genomically characterized cell lines with data available

genomically characterized pdx with data available1

genomically characterized pdx with data available

How do I get access to the specimens?

To request any of the biospecimens, or pre-clinical model please fill out this form.
Request take approx. 3 months and will require review by the scientific committee and MTA.
Need help? Contact us at research@cbtn.org

Explore the data in these informatics portals

How do I get access to the data?

To access the data please follow these instructions. Need help? Contact us at research@cbtn.org
You can access processed data today here by simply logging in to PedcBioPortal
You can request raw data by completing this form. The review normally takes 1 week. Once approved you can access the raw data by creating cohorts of interest on the Kids First Data Resource Portal and performing analysis on the cloud in Cavatica