High-grade glioma/astrocytoma (WHO grade III/IV)
High-grade Gliomas (HGG) in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric specific HGG preclinical models. These models are needed to help test the effectiveness of different drug types in the laboratory. Medical advances over the last 40 years have increased the survival rates for many types of childhood cancers. However, the prognosis for patients diagnosed with a Diffuse Intrinsic Pontine Glioma (DIPG) has not improved. These highly-aggressive brain tumors defy treatment and have a 98% mortality rate,typically within nine months of a diagnosis. Located in the area of the brainstem that controls a child’s breathing, blood pressure, heart rate, and other vital functions, DIPG tumors cannot be removed through surgery. WHO 2016 Classification Diffuse astrocytic and oligodendroglial tumor.
How many participants are enrolled?
Available CBTN Biospecimens
participants with flash-frozen tissue available
participants with match blood
participants with match parental specimens
participants with cerebral spinal fluid
Available CBTN Pre-clinical Models
genomically characterized cell lines with data available
genomically characterized pdx with data available
Projects supported by the CBTN
Data projects supported
Specimen projects supported
What type of data are available?
Project Hope: High-Grade Glioma-Omics in Pediatric and AYA
Our overall objective of the project is the implementation of single-cell sequencing techniques in the context of a multiomics approach that includes bulk WGS, RNAseq, and total/phospho proteomics to investigate pediatric and AYA HGG biology. Analyses will focus on biospecimens collected across m
Elucidating the Role of Driver Mutations in Pediatric High Grade Glioma
High grade pediatric brain tumors (pHGG) are a devastating disease with a median survival of only 9-15 months. Importantly, pHGG represent the greatest cause of cancer related death in children under 19 years of age even though the overall incidence is low (1.78/100,000). In recent years it has b
Thomas De Raedt
Precision imaging of pediatric high grade gliomas with quantitative diffusion weighted imaging and texture analysis to identify imaging biomarkers that predict tumor genetics and patient outcomes
Pediatric high grade gliomas are molecularly different from adult gliomas and in comparison to adults, children with high grade gliomas have persistently poor clinical outcomes. Molecular markers have been shown to be important for treatment of adult gliomas, and new molecular markers for pediatr
How do I get access to the specimens?
To request any of the biospecimens, or pre-clinical model please fill out this form.
Request take approx. 3 months and will require review by the scientific committee and MTA.
Need help? Contact us at firstname.lastname@example.org
How do I get access to the data?
To access the data please follow these instructions. Need help? Contact us at email@example.com
You can access processed data today here by simply logging in to PedcBioPortal
You can request raw data by completing this form. The review normally takes 1 week. Once approved you can access the raw data by creating cohorts of interest on the Kids First Data Resource Portal and performing analysis on the cloud in Cavatica
Flash frozen tissue is tissue from a surgical procedure where the tissue is frozen instantly in liquid nitrogen to ensure there is no degradation
Tissue in freezing media is tissue from a surgical procedure where the tissue is frozen 1 degree at a time over a 24-hour period to keep the tissue intact and compatible with regrowing the tumor for testing
Matched blood is blood that is collected from the patient in addition to tissue from the tumor. This blood provides researchers a direct comparison between normal and tumor specimens for this specific patient
Cerebral Spinal Fluid (CFS) is fluid taken from the the nervous system that researchers can use to study brain tumors
Paternal and maternal specimens are specimens taken from the biological parents of the subject. These specimens provide researchers with the ability to compare tumor and normal tissue and predispositions