High-grade glioma/astrocytoma (WHO grade III/IV)


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enrolled participants

Data Projects Supported
Specimen Projects Supported
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Summary of

High-grade glioma/astrocytoma (WHO grade III/IV)

High-grade Gliomas (HGG) in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric specific HGG preclinical models. These models are needed to help test the effectiveness of different drug types in the laboratory. Medical advances over the last 40 years have increased the survival rates for many types of childhood cancers. However, the prognosis for patients diagnosed with a Diffuse Intrinsic Pontine Glioma (DIPG) has not improved. These highly-aggressive brain tumors defy treatment and have a 98% mortality rate,typically within nine months of a diagnosis. Located in the area of the brainstem that controls a child’s breathing, blood pressure, heart rate, and other vital functions, DIPG tumors cannot be removed through surgery. WHO 2016 Classification Diffuse astrocytic and oligodendroglial tumor.

available HGG


How many participants are enrolled?

348Participants Enrolled

Available CBTN Biospecimens

participants with flash-frozen tissue available329

participants with flash-frozen tissue available

participants with match blood168

participants with match blood

participants with match parental specimens25

participants with match parental specimens

participants with cerebral spinal fluid29

participants with cerebral spinal fluid

Available CBTN Pre-clinical Models

genomically characterized cell lines with data available38

genomically characterized cell lines with data available

genomically characterized pdx with data available1

genomically characterized pdx with data available

Projects supported by the CBTN

Data projects supported2

Data projects supported

Specimen projects supported40

Specimen projects supported

Explore the data in these informatics portals


How do I get access to the specimens?

To request any of the biospecimens, or pre-clinical model please fill out this form.
Request take approx. 3 months and will require review by the scientific committee and MTA.
Need help? Contact us at research@cbtn.org

How do I get access to the data?

To access the data please follow these instructions. Need help? Contact us at research@cbtn.org
You can access processed data today here by simply logging in to PedcBioPortal
You can request raw data by completing this form. The review normally takes 1 week. Once approved you can access the raw data by creating cohorts of interest on the Kids First Data Resource Portal and performing analysis on the cloud in Cavatica

Flash frozen tissue is tissue from a surgical procedure where the tissue is frozen instantly in liquid nitrogen to ensure there is no degradation

Tissue in freezing media is tissue from a surgical procedure where the tissue is frozen 1 degree at a time over a 24-hour period to keep the tissue intact and compatible with regrowing the tumor for testing

Matched blood is blood that is collected from the patient in addition to tissue from the tumor. This blood provides researchers a direct comparison between normal and tumor specimens for this specific patient

Cerebral Spinal Fluid (CFS) is fluid taken from the the nervous system that researchers can use to study brain tumors

Paternal and maternal specimens are specimens taken from the biological parents of the subject. These specimens provide researchers with the ability to compare tumor and normal tissue and predispositions