The current standard of care for treatment of pediatric patients with high grade gliomas is surgery followed by radiotherapy with concurrent chemotherapy. Midline gliomas with histone H3 K27M mutation are a new class of malignant gliomas that present specific challenges. These challenges include having extremely poor prognosis due to being located in regions of the brain where surgery is difficult. Pediatric high grade gliomas are molecularly different from adult gliomas and in comparison to adults, children with high grade gliomas have persistently poor clinical outcomes. Molecular markers have been shown to be important for treatment of adult gliomas. The recently characterized molecular marker, histone H3 K27M, could prove similarly important in the treatment of pediatric gliomas. Due to invasive potentially site-limited availability of molecular testing, there is a critical need to identify imaging biomarkers of pediatric high grade gliomas. Researchers are looking for biomarkers that could predict tumor molecular markers used as therapy targets, tumor response to radiotherapy and chemotherapy, and clinical performance levels of children undergoing treatment. The goal of the proposed study is to identify imaging markers that predict the molecular markers, histologic features, and clinical outcomes in a cohort of pediatric patients with high grade gliomas. Researchers will do this using data from patients that underwent tissue sampling, genetic analysis of tumor tissue, and at least a 12 month follow up, available through the Pediatric Brain Tumor Atlas.
What are the goals of this project?
The goal of this project is to deepen the understanding of the malignant form of glioma, midline gliomas with histone H3 K27M mutations.
What is the impact of this project?
Researchers are hoping to find imaging biomarkers that could be used as therapy targets, predict tumor response to radiotherapy and chemotherapy, and increase clinical performance levels of children undergoing treatment.
Why is the CBTN request important to this project?
Researchers require data from patients that underwent tissue samples, genetic analysis of that tissue, and had a 12 month follow up, data made available only through the Pediatric Brain Tumor Atlas.
Dr. Soonmee Cha , UCSF
Mariam Aboian, MD, PhD
Dr. Aboian's background training and clinical experience is focused on neuroimaging of primary brain tumors and metastatic cancer to the brain with dedicated subspecialty training in neuroradiology and nuclear medicine. The focus of my research is to identify imaging biomarkers that predict tumor ty
Yale School of Medicine
Cassie Kline, MD, MAS
Pediatric Neuro-Oncology, Clinical research, Early phase clinical trials in neuro-oncology, Developmental therapeutics
Children’s Hospital of Philadelphia
Sabine Mueller, MD, PhD
Dr. Sabine Mueller is a pediatric neuro-oncologist who specializes in caring for children with brain tumors and related genetic syndromes. Before completing medical school, she worked as a scientist, director of genomics and project leader for a brain tumor program at AGY Therapeutics, a biotechnolo
UCSF Benioff Children's Hospital
Yale School of Medicine
Children’s Hospital of PhiladelphiaJoined on
Operations Center for the Children’s Brain Tumor Tissue Consortium, the Children’s Hospital of Philadelphia (CHOP) is currently ranked 1st nationally for their Pediatric Cancer Program by U.S. News & World Report. CHOP’s Biobank is home to the CBTTC’s pediatric brain and CNS tumor biorepository; the
UCSF Benioff Children's HospitalJoined on
The Pediatric Brain Tumor Center at UCSF Benioff Children’s Hospital, with campuses in San Francisco and Oakland, harnesses the power of world-class experts from all disciplines related to child brain health, including neurology, neurosurgery, neurocritical care, neurogenetics, neuro-oncology, rehab
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