Professor of Clinical Neurology

UCSF Benioff Children's Hospital

Dr. Sabine Mueller is a pediatric neuro-oncologist who specializes in caring for children with brain tumors and related genetic syndromes. Before completing medical school, she worked as a scientist, director of genomics and project leader for a brain tumor program at AGY Therapeutics, a biotechnology company in South San Francisco.

In her research, Mueller studies treatments for children with brain tumors, looking especially at improving long-term cognitive outcomes.

Mueller earned her medical degree at the Universität Hamburg Faculty of Medicine and earned a doctorate in biochemistry and molecular biology in collaboration with AGY. After a residency in pediatrics at Massachusetts General Hospital, she completed a fellowship in pediatric oncology at UCSF.

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UCSF Benioff Children's Hospital

San Francisco and Oakland, CA, USA



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Oncolytic Virus to Potentiate Immune-checkpoint Blockade in Immunologically Cold Pediatric Brain Tumors

The use of an oncolytic virus refers to the use of a virus to stimulate immune response in a tumor. Researchers will utilize carefully catalogued samples provided by the Children’s Brain Tumor Network to further explore the use of oncolytic viruses in the treatment of pediatric brain cancers.



Aaron Diaz

UCSF Benioff Children's Hospital
San Francisco and Oakland, CA, USA
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Precision Imaging of Pediatric High-grade Gliomas with Quantitative Diffusion Weighted Imaging and Texture Analysis to Identify Imaging Biomarkers That Predict Tumor Genetics and Patient Outcomes

The recently characterized molecular marker, histone H3 K27M, could prove important to the treatment of pediatric gliomas. Researchers will interrogate data from the Pediatric Brain Tumor Atlas in order to better understand this new class of malignant gliomas.


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Mariam Aboian

Yale School of Medicine
New Haven, CT, USA
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Integrative Analysis of Childhood Cancers

Integrative research is needed to advance the treatment options for pediatric cancers. Researchers will analyze data provided through the Pediatric Brain Tumor Atlas in an effort to identify new opportunities in the treatment of pediatric cancers.

All Brain Tumor Types

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Charlie Vaske

Culver City, California
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PNOC and SJCRH Collaborative DIPG Radiogenomic Investigation

Tumor classification through imaging is an important part of pediatric cancer diagnosis and treatment. Researchers will investigate tumor imagery and genomic data provided by the Children’s Brain Tumor Network in an effort to advance the accuracy of tumor classification.


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Using histopathology to discover genetic alterations in pediatric brain tumors

In depth understanding of the molecular make up of brain tumors is critical to inform therapy decision making. Often tumor tissue is limited for this type of analysis and it will be very beneficial to derive detail molecular information from basic pathology slides. Herein we aim to use machine learning to develop such program that will allow us to predict the molecular make up based on analysis of standard pathology slides. Funding for the project was provided by Ian’s Friends Foundation.

All Brain Tumor Types


Sabine Mueller

UCSF Benioff Children's Hospital
San Francisco and Oakland, CA, USA



Indigenous Inclusion
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