Assistant Professor of Clinical Neurology
UCSF Benioff Children's Hospital
Dr. Sabine Mueller is a pediatric neuro-oncologist who specializes in caring for children with brain tumors and related genetic syndromes. Before completing medical school, she worked as a scientist, director of genomics and project leader for a brain tumor program at AGY Therapeutics, a biotechnology company in South San Francisco.
In her research, Mueller studies treatments for children with brain tumors, looking especially at improving long-term cognitive outcomes.
Mueller earned her medical degree at the Universität Hamburg Faculty of Medicine and earned a doctorate in biochemistry and molecular biology in collaboration with AGY. After a residency in pediatrics at Massachusetts General Hospital, she completed a fellowship in pediatric oncology at UCSF.
UCSF Benioff Children's Hospital
Oncolytic Virus to Potentiate Immune-checkpoint Blockade in Immunologically Cold Pediatric Brain Tumors
The use of an oncolytic virus refers to the use of a virus to stimulate immune response in a tumor. Researchers will utilize carefully catalogued samples provided by the Children’s Brain Tumor Network to further explore the use of oncolytic viruses in the treatment of pediatric brain cancers.
Precision Imaging of Pediatric High-grade Gliomas with Quantitative Diffusion Weighted Imaging and Texture Analysis to Identify Imaging Biomarkers That Predict Tumor Genetics and Patient Outcomes
The recently characterized molecular marker, histone H3 K27M, could prove important to the treatment of pediatric gliomas. Researchers will interrogate data from the Pediatric Brain Tumor Atlas in order to better understand this new class of malignant gliomas.
Integrative Analysis of Childhood Cancers
Integrative research is needed to advance the treatment options for pediatric cancers. Researchers will analyze data provided through the Pediatric Brain Tumor Atlas in an effort to identify new opportunities in the treatment of pediatric cancers.
All Brain Tumor Types
PNOC and SJCRH Collaborative DIPG Radiogenomic Investigation
Tumor classification through imaging is an important part of pediatric cancer diagnosis and treatment. Researchers will investigate tumor imagery and genomic data provided by the Children’s Brain Tumor Network in an effort to advance the accuracy of tumor classification.
Using histopathology to discover genetic alterations in pediatric brain tumors
In depth understanding of the molecular make up of brain tumors is critical to inform therapy decision making. Often tumor tissue is limited for this type of analysis and it will be very beneficial to derive detail molecular information from basic pathology slides. Herein we aim to use machine learning to develop such program that will allow us to predict the molecular make up based on analysis of standard pathology slides.
All Brain Tumor Types
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test
Low-Grade Gliomas also called astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still su
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with
CBTN Annual Investigator Meeting
Precision Medicine Approaches for Children with DIPG
Recent advances in gene expression and sequencing technologies allow oncologists for the first time to use these technologies in real time for clinical decision making and to determine an individualized treatment plan based on each child’s tumor characteristics. Our first feasibility trial used a pr
Children's Brain Tumor Network - Accelerating Research Through Collaboration and Open Science
This presentation highlights the impact and importance of the collaborative and open source nature of CBTN databases and samples.
Jena Lilly, Jennifer Mason, Elizabeth Appert, Allison Heath, Yuankun Zhu, Bo Zhang, Mateusz Koptyra, Mariarita Santi, Ian Pollack, Stewart Goldman, Sarah Leary, Anna Buccoliero, Mirko Scagnet, David Haussler, Derek Hanson, Jiangguo Zhang, Weiqing Wan, Chunde Li, Ron Firestein, Jason Cain, Joanna Phillips, Nalin Gupta, Sabine Mueller, Gerald Grant, Michelle Monje-Deisseroth, Sonia Partap, Jeffrey Greenfield, Brian Rood, Javad Nazarian, Eric Raabe, Eric Jackson, Stacie Stapleton, Robert Lober, David Kram, Phillip Storm, Rishi Lulla, Michael Prados, Adam Resnick, and Angela Waanders
Scientific Reports - Nature
Harmonization of Postmortem Donations for Pediatric Brain Tumors and Molecular Characterization of Diffuse Midline Gliomas
The whole genome sequencing and RNA sequencing data related to pediatric diffuse midline gliomas that is generated by researchers on this project will be shared widely with support from CBTN.
Kambhampati M, Panditharatna E, Yadavilli S, Saoud K, Lee S, Eze A, Almira-Suarez MI, Hancock L, Bonner ER, Gittens J, Stampar M, Gaonkar K, Resnick AC, Kline C, Ho C-Y, Waanders AJ, Georgescu M-M, Rance NE, Kim Y, Johnson C, Rood BR, Kilburn LB, Hwang EI, Mueller S, Packer RJ, Bornhorst M, Nazarian J.