Professor of Clinical Neurology
UCSF Benioff Children's Hospital
Dr. Sabine Mueller is a pediatric neuro-oncologist who specializes in caring for children with brain tumors and related genetic syndromes. Before completing medical school, she worked as a scientist, director of genomics and project leader for a brain tumor program at AGY Therapeutics, a biotechnology company in South San Francisco.
In her research, Mueller studies treatments for children with brain tumors, looking especially at improving long-term cognitive outcomes.
Mueller earned her medical degree at the Universität Hamburg Faculty of Medicine and earned a doctorate in biochemistry and molecular biology in collaboration with AGY. After a residency in pediatrics at Massachusetts General Hospital, she completed a fellowship in pediatric oncology at UCSF.
UCSF Benioff Children's Hospital
Oncolytic Virus to Potentiate Immune-checkpoint Blockade in Immunologically Cold Pediatric Brain Tumors
The use of an oncolytic virus refers to the use of a virus to stimulate immune response in a tumor. Researchers will utilize carefully catalogued samples provided by the Children’s Brain Tumor Network to further explore the use of oncolytic viruses in the treatment of pediatric brain cancers.
Precision Imaging of Pediatric High-grade Gliomas with Quantitative Diffusion Weighted Imaging and Texture Analysis to Identify Imaging Biomarkers That Predict Tumor Genetics and Patient Outcomes
The recently characterized molecular marker, histone H3 K27M, could prove important to the treatment of pediatric gliomas. Researchers will interrogate data from the Pediatric Brain Tumor Atlas in order to better understand this new class of malignant gliomas.
Integrative Analysis of Childhood Cancers
Integrative research is needed to advance the treatment options for pediatric cancers. Researchers will analyze data provided through the Pediatric Brain Tumor Atlas in an effort to identify new opportunities in the treatment of pediatric cancers.
All Brain Tumor Types
PNOC and SJCRH Collaborative DIPG Radiogenomic Investigation
Tumor classification through imaging is an important part of pediatric cancer diagnosis and treatment. Researchers will investigate tumor imagery and genomic data provided by the Children’s Brain Tumor Network in an effort to advance the accuracy of tumor classification.
Using histopathology to discover genetic alterations in pediatric brain tumors
In depth understanding of the molecular make up of brain tumors is critical to inform therapy decision making. Often tumor tissue is limited for this type of analysis and it will be very beneficial to derive detail molecular information from basic pathology slides. Herein we aim to use machine learning to develop such program that will allow us to predict the molecular make up based on analysis of standard pathology slides. Funding for the project was provided by Ian’s Friends Foundation.
All Brain Tumor Types
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test
Low-Grade Gliomas also called astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still su
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with
CBTN Annual Investigator Meeting
Precision Medicine Approaches for Children with DIPG
Recent advances in gene expression and sequencing technologies allow oncologists for the first time to use these technologies in real time for clinical decision making and to determine an individualized treatment plan based on each child’s tumor characteristics. Our first feasibility trial used a pr
Indigenous peoples and inclusion in clinical and genomic research: Understanding the history and navigating contemporary engagement
The survival rates for pediatric cancer patients have improved significantly, but there are still significant disparities among underrepresented racial and ethnic groups. To address this issue, the Pacific Pediatric Neuro-Oncology Consortium (PNOC) and Children's Brain Tumor Network (CBTN) created a
Angela Waanders, Alex Brown, Nadine R. Caron, Alexa Plisiewicz, Sean T. McHugh, Thinh Q. Nguyen, Kaitlin Lehmann, Jeffrey Stevens, Phillip J. Storm, Adam Resnick, Tom Belle Davidson, Sabine Mueller, Cassie Kline
Past, present and future of Focused Ultrasound as an adjunct or complement to DIPG/DMG therapy: A consensus of the 2021 FUSF DIPG meeting
Diffuse Midline Glioma (DMG) is a type of brain tumor that mainly affects children and has limited treatment options and a poor prognosis. One of the major obstacles to treating DMG is the blood-brain barrier, which prevents most drugs from reaching the tumor. Focused Ultrasound (FUS) is a noninvasi
Kavya Parekh, Suzanne LeBlang, Javad Nazarian, Sabine Mueller, Stergios Zacharoulis, Kullervo Hynynen, Lauren Powlovich
Retrospective dataset and survey analyses identify gaps in data collection for craniopharyngioma and priorities of patients and families affected by the disease
Craniopharyngioma is a rare type of brain tumor located in the suprasellar region of the brain, close to important structures like the pituitary gland. This study aimed to better understand patient outcomes associated with existing therapies and to inform new treatment strategies. Our team collected
Emily Marshall, Nikhil Joshi, Julia Crowley, Shana McCormack, Sylvia Cheng, Walter Faig, Phillip B. Storm, Adam Resnick, Sabine Mueller, Fatema Malbari, Cassie Kline
Pediatric low-grade glioma: Targeted therapeutics and clinical trials in the molecular era
Pediatric Low-Grade Gliomas (pLGGs) are a type of brain tumor found in children. This article outlines some of the recent advances in understanding the genetic changes that cause these tumors have led to new treatments that target specific genes. This has allowed doctors to offer targeted therap
Neevika Manoharan, Kevin X. Liu, Sabine Mueller, Daphne A. Haas-Kogan, Pratiti Bandopadhayay
Interdisciplinary care of children with diffuse midline glioma
Diffuse Midline Glioma (DMG) which includes Diffuse Intrinsic Pontine Glioma (DIPG) is an infiltrative tumor of the midline structures of the central nervous system that demonstrates an aggressive pattern of growth and has no known curative treatment. As these tumors progress, children experience on
Christina Coleman, Katherine Chen, Alex Lu, Elizabeth Seashore, Schuyler Stoller, Taron Davis, Steve Braunstein, Nalin Gupta, Sabine Mueller