The genetic analysis and imaging of tumors is necessary for medical professionals to diagnose and treat patients with pediatric brain cancer. Most cancer patients are imaged with CT, PET or MRI because such imaging reveals that tumors are complex, often containing many distinct subregions within them. This information allows for the classification of tumors, which guides the treatment decisions of medical professionals. Researchers hope that exploring the connections between tumor imaging and genomics will facilitate improved classification of patient tumors and better outcomes. The second goal is to develop a deeper understanding of the connection between the changes and growth of tumor subregions and changes in bodily fluids collected from the same tumors, making diagnosis, prognosis, and treatment methods more accurate and effective. The Children’s Brain Tumor Network will provide researchers with the clinical, genomic, and imaging data necessary to complete this analysis across pediatric brain cancer types.
What are the goals of this project?
Researchers will explore the connections between tumor imaging data and genomic data and work to develop a better understanding of tumor subregions and the ways they change throughout treatment.
What is the impact of this project?
Studying these correlations between different types of pediatric brain cancer data could make diagnosis and prognosis more accurate while also opening the door to new therapeutic options.
Why is the CBTN request important to this project?
The Children’s Brain Tumor Network will be supporting researchers on this project by providing the clinical, genomic, and imaging data necessary for analysis across a broad set of pediatric brain cancer types.
The Children's Brain Tumor Network contributed to this project by providing clinical, genomic and imaging data.
PI: John Lucas, St. Jude Children's Hospital
Christopher Tinkle, St. Jude Children's Hospital
Chi-Yang Hsu, St. Jude Children's Hospital
Zoltan Patay, St. Jude Children's Hospital
Gang Wu, Bioinformatician, St. Jude Children's Hospital
Adam Resnick, PhD
Adam Resnick is the Director of Data Driven Discovery in Biomedicine (D3b) at Children’s Hospital of Philadelphia (CHOP) responsible for leading a multidisciplinary team to build and support a scalable, patient-focused healthcare and educational discovery ecosystem on behalf of all children. He is a
Children’s Hospital of Philadelphia
Sabine Mueller, MD, PhD
Dr. Sabine Mueller is a pediatric neuro-oncologist who specializes in caring for children with brain tumors and related genetic syndromes. Before completing medical school, she worked as a scientist, director of genomics and project leader for a brain tumor program at AGY Therapeutics, a biotechnolo
UCSF Benioff Children's Hospital
Children’s Hospital of PhiladelphiaJoined on
Operations Center for the Children’s Brain Tumor Tissue Consortium, the Children’s Hospital of Philadelphia (CHOP) is currently ranked 1st nationally for their Pediatric Cancer Program by U.S. News & World Report. CHOP’s Biobank is home to the CBTTC’s pediatric brain and CNS tumor biorepository; the
UCSF Benioff Children's HospitalJoined on
The Pediatric Brain Tumor Center at UCSF Benioff Children’s Hospital, with campuses in San Francisco and Oakland, harnesses the power of world-class experts from all disciplines related to child brain health, including neurology, neurosurgery, neurocritical care, neurogenetics, neuro-oncology, rehab
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with