Integrative Analysis of Childhood Cancers

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The team, lead by Dr. Vaske is generating mutational, transcriptional, and integrative profiles of individual tumors. Integrative profiles will summarize mutation and expression features at the pathway level, or by other groupings. They also are comparing the profiles of CBTN samples to each other to find sub-groupings of samples, and determine which features define those groupings, as well as potential gene targets within that group. They will also compare the CBTN samples to other human mutational, transcriptional, and integrative profiles, from benign tissue, cancerous tissue, and cell lines in various conditions. The purpose of these comparisons will be to further refine the set of potential gene and pathway targets. Finally, they are intersecting the list of subgroup-target pairs with known therapeutic agents, to identify potential novel therapies that could be tested in suitable situations.

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What are the goals of this project?

We will apply integrative analysis of data types to find potential novel drug targets and matching of therapeutics.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals


Meet The



  • Zack Sanborn at NantOmics
  • Yulia Newton at NantOmics
  • AJ Sedgewick at NantOmics
  • Bobby Reddy at NantHealth
  • Kayvan Niazi at NantBio
  • Lennie Sender at NantKwest