Treating pediatric cancers requires a robust understanding of the mechanisms of tumor growth and progression, as well as an understanding of the differences between tumor types. This project seeks to generate mutational, transcriptional, and integrative profiles of individual tumors. Researchers will compare samples to each other to find sub-groupings of samples, and determine which features define those groupings. Understanding these groupings could lead to the identification of targets for therapeutics. The purpose of these comparisons will be to further refine the set of potential gene and pathway targets for the treatment of pediatric brain cancers. Researchers will apply integrative analysis of data types to find potential novel drug targets and matching of therapeutics. The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
What are the goals of this project?
Researchers will analyze pediatric cancer data to characterize key elements of the tumors.
What is the impact of this project?
Understanding the key characteristics for tumor types will provide improvement to identify potential new diagnostic indicators and therapeutic targets.
Why is the CBTN request important to this project?
Work like this project requires comprehensive, high quality data across cancer types, making access to the Pediatric Brain Tumor Atlas integral.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
- Zack Sanborn at NantOmics
- Yulia Newton at NantOmics
- AJ Sedgewick at NantOmics
- Bobby Reddy at NantHealth
- Kayvan Niazi at NantBio
- Lennie Sender at NantKwest
Olena Morozova Vaske, PhD
Dr. Vaske is the Co-Founder of the Treehouse Childhood Cancer Initiative at the University of California Santa Cruz Genomics Institute where she is an Assistant Professor of Molecular, Cell and Developmental Biology. She is a Fellow of the Canadian College of Medical Geneticists and holds the Univer
UC Santa Cruz Treehouse Childhood Cancer Initiative
Sabine Mueller, MD, PhD
Dr. Sabine Mueller is a pediatric neuro-oncologist who specializes in caring for children with brain tumors and related genetic syndromes. Before completing medical school, she worked as a scientist, director of genomics and project leader for a brain tumor program at AGY Therapeutics, a biotechnolo
UCSF Benioff Children's Hospital
Adam Resnick, PhD
Adam Resnick is the Director of Data Driven Discovery in Biomedicine (D3b) at Children’s Hospital of Philadelphia (CHOP) responsible for leading a multidisciplinary team to build and support a scalable, patient-focused healthcare and educational discovery ecosystem on behalf of all children. He is a
Children’s Hospital of Philadelphia
Javad Nazarian, PhD, MSc
I am an investigator at the Center for Genetic Medicine in Children’s National Hospital in Washington, D.C., and an assistant professor in Integrative Systems Biology at the George Washington University. I received my PhD from the George Washington University in Genetics in 2005. My dissertation res
Children’s National Hospital
Our mission is to provide comprehensive personalized molecular solutions to inform cancer care.NantOmics, a member of the NantWorks ecosystem of companies, is a leader in molecular diagnostic testing and the first company to employ an integrated panomic approach to inform personalized treatment opti
UC Santa Cruz Treehouse Childhood Cancer InitiativeJoined on
The Treehouse Childhood Cancer Initiative was established to analyze genomic data of children with cancer in the context of large data sets of both pediatric and adult cancers. This allows researchers to identify situations where an available drug is predicted to work for a given patient’s tumor. Tr
UCSF Benioff Children's HospitalJoined on
The Pediatric Brain Tumor Center at UCSF Benioff Children’s Hospital, with campuses in San Francisco and Oakland, harnesses the power of world-class experts from all disciplines related to child brain health, including neurology, neurosurgery, neurocritical care, neurogenetics, neuro-oncology, rehab
Children’s Hospital of PhiladelphiaJoined on
Operations Center for the Children’s Brain Tumor Tissue Consortium, the Children’s Hospital of Philadelphia (CHOP) is currently ranked 1st nationally for their Pediatric Cancer Program by U.S. News & World Report. CHOP’s Biobank is home to the CBTTC’s pediatric brain and CNS tumor biorepository; the
Children’s National HospitalJoined on
Each year, the Brain Tumor Institute at Children’s National evaluates more than 100 new patients with brain tumors, and is recognized as a world leader in childhood brain tumor care and research. Children’s National has pioneered novel pediatric brain tumor therapies, including new molecularly-targe