The team, lead by Dr. Vaske is generating mutational, transcriptional, and integrative profiles of individual tumors. Integrative profiles will summarize mutation and expression features at the pathway level, or by other groupings. They also are comparing the profiles of CBTN samples to each other to find sub-groupings of samples, and determine which features define those groupings, as well as potential gene targets within that group. They will also compare the CBTN samples to other human mutational, transcriptional, and integrative profiles, from benign tissue, cancerous tissue, and cell lines in various conditions. The purpose of these comparisons will be to further refine the set of potential gene and pathway targets. Finally, they are intersecting the list of subgroup-target pairs with known therapeutic agents, to identify potential novel therapies that could be tested in suitable situations.
What are the goals of this project?
We will apply integrative analysis of data types to find potential novel drug targets and matching of therapeutics.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
- Zack Sanborn at NantOmics
- Yulia Newton at NantOmics
- AJ Sedgewick at NantOmics
- Bobby Reddy at NantHealth
- Kayvan Niazi at NantBio
- Lennie Sender at NantKwest
Olena Morozova Vaske, PhD
Dr. Vaske is the Co-Founder of the Treehouse Childhood Cancer Initiative at the University of California Santa Cruz Genomics Institute where she is an Assistant Professor of Molecular, Cell and Developmental Biology. She is a Fellow of the Canadian College of Medical Geneticists and holds the Uni
UC Santa Cruz Treehouse Childhood Cancer Initiative
Sabine Mueller, MD, PhD
Dr. Sabine Mueller is a pediatric neuro-oncologist who specializes in caring for children with brain tumors and related genetic syndromes. Before completing medical school, she worked as a scientist, director of genomics and project leader for a brain tumor program at AGY Therapeutics, a biotechn
UCSF Benioff Children's Hospital
Adam Resnick, PhD
Adam Resnick is the Director of Data Driven Discovery in Biomedicine (D3b) at Children’s Hospital of Philadelphia (CHOP) responsible for leading a multidisciplinary team to build and support a scalable, patient-focused healthcare and educational discovery ecosystem on behalf of all children. He i
Children’s Hospital of Philadelphia
Javad Nazarian, PhD, MSc
I am an investigator at the Center for Genetic Medicine in Children’s National Hospital in Washington, D.C., and an assistant professor in Integrative Systems Biology at the George Washington University. I received my PhD from the George Washington University in Genetics in 2005. My dissertation
Children’s National Hospital