Using histopathology to discover genetic alterations in pediatric brain tumors
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Ask The
Scientists
What are the goals of this project?
We will empower our study with 1,000 adult glioma patients for which digitized histopathology images and matched genomic data are available and we will employ deep transfer learning techniques to predict driver gene alterations (eg, TP53, PIK3CA, ATRX, NF1) in pediatric brain tumors with models that were trained with data from adult glioma patients.
What is the impact of this project?
This project will potentially describe the molecular basis of pediatric brain tumor histopathology and provide a basis for integrating molecular and histopathological data to improve diagnostic and prognostic workflows for personalized treatments of children with CNS malignancies.
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Meet The
Team
Institutions
Primary
UCSF Benioff Children's Hospital
Joined onThe Pediatric Brain Tumor Center at UCSF Benioff Children’s Hospital, with campuses in San Francisco and Oakland, harnesses the power of world-class experts from all disciplines related to child brain health, including neurology, neurosurgery, neurocritical care, neurogenetics, neuro-oncology, rehab
University of Oslo
Center for Molecular Medicine Norway (NCMM)
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