Center for Molecular Medicine Norway (NCMM), University of Oslo
My lab focuses on precision medicine for children, adolescents, and young adults with cancer; in particular children with brain tumours. We combine approaches from population genomics, cancer genomics, and systems genetics to understand the genetic basis of cancer, the somatic evolution of cancer cells, and the mechanisms that drive genome and proteome instability in cancer. We further aim to improve the diagnosis, prognosis, and therapeutic recommendations for brain cancer patients based on the development of novel computational approaches that integrate multiple layers of molecular information.
University of Oslo
Landscape of Germline Histone Mutations in Pediatric Brain Tumor Patients
Research is needed to better understand the underlying cause of diffuse midline gliomas (DMGs). Using data provided by the Children’s Brain Tumor Atlas, researchers on this project will investigate mutations affecting histones in DMGs.
Using histopathology to discover genetic alterations in pediatric brain tumors
In depth understanding of the molecular make up of brain tumors is critical to inform therapy decision making. Often tumor tissue is limited for this type of analysis and it will be very beneficial to derive detail molecular information from basic pathology slides. Herein we aim to use machine learning to develop such program that will allow us to predict the molecular make up based on analysis of standard pathology slides. Funding for the project was provided by Ian’s Friends Foundation.
All Brain Tumor Types
Genetic Architecture of Molecular Phenotypes in Pediatric Brain Cancers
The identification of germline protein expression in brain cancer cells is pivotal in guiding the development of new treatments.s. Using the Pediatric Brain Tumor Atlas, researchers seek to create an important resource on the details of protein expression across many individual brain cancer types.
All Brain Tumor Types
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with
Clinical Cancer Research
Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003
PNOC003 is a multicenter precision medicine trial for children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG).
Cassie Kline, Payal Jain, Lindsay Kilburn, Erin R. Bonner, Nalin Gupta, John R. Crawford, Anu Banerjee, Roger J. Packer; Javier Villanueva-Meyer, Tracy Luks, Yalan Zhang, Madhuri Kambhampati, Jie Zhang, Sridevi Yadavilli, Bo Zhang, Krutika S. Gaonkar, Jo Lynne Rokita, Adam Kraya, John Kuhn, Winnie Liang; Sara Byron, Michael Berens, Annette Molinaro, Michael Prados, Adam Resnick, Sebastian M. Waszak, Javad Nazarian, Sabine Mueller