Low-Grade astrocytomas

LGG

Default histology image
1003

enrolled participants

name
8
Data Projects Supported
name
8
Specimen Projects Supported
Explore Projects

Summary of

Low-Grade astrocytomas

Low-Grade astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still suffer from the effects of a tumor, which may result in higher rates of morbidity and mortality. The available treatment options for children are limited in recurrent and/or disseminated, or circulated tumors, as well as those with tumors not suited for surgical resection. To date, this significant, un-met need for more effective, targeted therapeutics for children with unresectable or progressive astrocytomas has not yet been satisfied.

available LGG

Resources

How many participants are enrolled?

1003Participants Enrolled

Available CBTN Biospecimens

participants with flash-frozen tissue available844

participants with flash-frozen tissue available

participants with match blood469

participants with match blood

participants with match parental specimens71

participants with match parental specimens

participants with cerebral spinal fluid47

participants with cerebral spinal fluid

Available CBTN Pre-clinical Models

genomically characterized cell lines with data available3

genomically characterized cell lines with data available

genomically characterized pdx with data available0

genomically characterized pdx with data available

Projects supported by the CBTN

Data projects supported0

Data projects supported

Specimen projects supported8

Specimen projects supported

Explore the data in these informatics portals

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How do I get access to the specimens?

To request any of the biospecimens, or pre-clinical model please fill out this form.
Request take approx. 3 months and will require review by the scientific committee and MTA.
Need help? Contact us at research@cbtn.org

How do I get access to the data?

To access the data please follow these instructions. Need help? Contact us at research@cbtn.org
You can access processed data today here by simply logging in to PedcBioPortal
You can request raw data by completing this form. The review normally takes 1 week. Once approved you can access the raw data by creating cohorts of interest on the Kids First Data Resource Portal and performing analysis on the cloud in Cavatica

Flash frozen tissue is tissue from a surgical procedure where the tissue is frozen instantly in liquid nitrogen to ensure there is no degradation

Tissue in freezing media is tissue from a surgical procedure where the tissue is frozen 1 degree at a time over a 24-hour period to keep the tissue intact and compatible with regrowing the tumor for testing

Matched blood is blood that is collected from the patient in addition to tissue from the tumor. This blood provides researchers a direct comparison between normal and tumor specimens for this specific patient

Cerebral Spinal Fluid (CFS) is fluid taken from the the nervous system that researchers can use to study brain tumors

Paternal and maternal specimens are specimens taken from the biological parents of the subject. These specimens provide researchers with the ability to compare tumor and normal tissue and predispositions