Delineating Pediatric Glioma Progression Using Single-nuclei SequencingEmail Principal Investigator
Alex's Lemonade Stand Foundation, Single-cell Pediatric Cancer Atlas
Low-grade gliomas are the most prevalent brain cancer among children. While patients with this type of cancer respond well to surgery, the majority experience recurrence after initial removal and require additional rounds of treatment. Deeper study is needed to better steer and prioritize post-removal treatment protocol. For the past year, researchers have been studying the immune microenvironment of over 1100 samples of pediatric cancers including those provided by the Children’s Brain Tumor Network. The overall aim of this proposal is to understand changes in malignant and non-malignant compartments of pediatric low-grade gliomas during the course of the disease in an effort to guide treatment. The goals of this project are to determine changes in tumors during the course of tumor progression and to investigate contribution and evolution of tumour microenvironment in the low-grade glioma. The Children's Brain Tumor Network will be contributing to this project by providing rare, high quality low grade glioma samples. By studying cancer and non-cancerous cell types that populate brain tumours upon recurrence, researchers expect to identify novel therapy targets and to develop combination therapy protocols informed by this work.
What are the goals of this project?
Researchers seek to understand how low grade gliomas change in their immune tumor microenvironment throughout progression and treatment and how the tumor microenvironment supports the tumor’s growth and progression in an effort to inform more personalized treatment protocol.
What is the impact of this project?
Through a better understanding of the changes undergone by low grade gliomas in the tumor microenvironment over the course of treatment, researchers hope to better optimize the use of single and combined therapies.
Why is the CBTN request important to this project?
The high quality low grade glioma samples available provided by the Children’s Brain Tumor Network are integral to the in depth nature of this study.
The Children's Brain Tumor Network will be contributing to this project by providing low grade glioma samples.
Low-Grade Gliomas also called astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still su
Ganglioglioma presents during childhood and into adulthood. It most commonly arises in the cerebral cortex and is associated with seizures, but also presents in other sites, including the spinal cord.[65,74]The unifying theme for the molecular pathogenesis of ganglioglioma is genomic alterations lea
Immunogenomic Landscape of Pediatric Cancers
The study of a tumor’s immune repertoire includes an analysis of T cell receptors and B cell receptors that allow an immune system to adapt to changes and launch an immune system response. Using the Pediatric Brain Tumor Atlas, researchers will study the immune repertoire across tumor types which could lead to new immunotherapies.
All Brain Tumor Types