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Trevor Pugh

University of Toronto
Toronto, ON M5T 1P5, Canada

CBTN Data

966

CBTN Participants

Backer

Terry Fox Research Institute added

About this

Project

The study of a tumor’s immune repertoire includes an analysis of T cell receptors and B cell receptors that allow an immune system to adapt to changes and launch an immune system response. Understanding the immune repertoire of pediatric tumors could lead to advancements in immunotherapy, a therapy that uses a patient’s own immune system to attack a tumor. Researchers will analyze data from pediatric brain tumors through access to the Pediatric Brain Tumor Atlas in a search for relevant features of the immune system that could be utilized in new immunotherapies.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

Researchers are looking to better understand the immune system of pediatric brain tumors through an analysis of T cell and B cell receptors.

What is the impact of this project?

An in-depth understanding of a tumor’s immune repertoire could guide researchers in developing treatments such as new immunotherapies.

Why is the CBTN request important to this project?

The broad set of data across pediatric brain tumor types provided through the Pediatric Brain Tumor Atlas is necessary to complete this work.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals

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Meet The

Team

Collaborators:

  • Arash Nabbi, PharmD, PhD - University Health Network
  • Dr. Uri Tabori, MD - The Hospital for Sick Children
  • Dr. Stefan Pfister, MD - Hopp-Children’s Cancer Center, Germany
  • Dr. David Jones, PhD - Hopp-Children’s Cancer Center, Germany
  • Dr. Jaeger, Hopp-Children’s Cancer Center, Germany
  • Dr Katherine Hutchinson, PhD - Genentech
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Trevor Pugh, PhD, FACMG

Cancer GenomicsClinical Molecular GeneticsBioinformaticsSoftware development

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University of Toronto

Toronto, ON M5T 1P5, Canada
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Arash Nabbi, PhD

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Uri Tabori, MD

The Tabori lab is focused on combining biological and translational research in paediatric oncology. Specifically, we are interested in studying mechanisms underlying brain tumor immortality and recurrence in the context of predisposition to cancer. Currently our group is studying 3 major areas rela

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Sick Kids

Toronto, Canada
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Stefan M. Pfister, MD

Our group aims to bridge the gap between generating genomic screening data as well as faithful models for preclinical drug testing, and exploiting these data for the sake of our patients.

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Marcel Kool, PhD

Preclinical model systems, high-throughput drug screens, shRNA screens, and CRISPR/Cas9 screens, to find new and better drug targets and for understanding tumor development and primary and acquired therapy-related resistance mechanisms

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Hopp Children's Cancer Center

Heidelberg, Germany
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David T.W. Jones, PhD

Our research in the area of HGG & DIPG aims at understanding the heterogeneity both within single tumors and between individuals, to identify the most important patterns of alterations in the cellular machinery. We then try to recapitulate these changes in model systems, in order to understand their

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Natalie Jäger, PhD

With our analyses, we significantly support the INFORM program, an international project to create personalized molecular tumor profiles for children with recurrent or refractory tumors. By analyzing the tumor data, we identify molecular changes that may represent potential targets for a given drug

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Katherine Hutchinson, PhD