Immunogenomic Landscape of Pediatric Cancers
Email Principal Investigator
Trevor Pugh
CBTN Data
CBTN Participants
Backer
Terry Fox Research Institute added
About this
Project
The study of a tumor’s immune repertoire includes an analysis of T cell receptors and B cell receptors that allow an immune system to adapt to changes and launch an immune system response. Understanding the immune repertoire of pediatric tumors could lead to advancements in immunotherapy, a therapy that uses a patient’s own immune system to attack a tumor. Researchers will analyze data from pediatric brain tumors through access to the Pediatric Brain Tumor Atlas in a search for relevant features of the immune system that could be utilized in new immunotherapies.
Ask The
Scientists
What are the goals of this project?
Researchers are looking to better understand the immune system of pediatric brain tumors through an analysis of T cell and B cell receptors.
What is the impact of this project?
An in-depth understanding of a tumor’s immune repertoire could guide researchers in developing treatments such as new immunotherapies.
Why is the CBTN request important to this project?
The broad set of data across pediatric brain tumor types provided through the Pediatric Brain Tumor Atlas is necessary to complete this work.
Specimen Data
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Explore the data in these informatics portals
Meet The
Team
Collaborators:
- Arash Nabbi, PharmD, PhD - University Health Network
- Dr. Uri Tabori, MD - The Hospital for Sick Children
- Dr. Stefan Pfister, MD - Hopp-Children’s Cancer Center, Germany
- Dr. David Jones, PhD - Hopp-Children’s Cancer Center, Germany
- Dr. Jaeger, Hopp-Children’s Cancer Center, Germany
- Dr Katherine Hutchinson, PhD - Genentech
Toronto, ON M5T 1P5, Canada
2500 University Dr NW, Calgary, AB T2N 1N4, Canada
Toronto, Canada
Heidelberg, Germany
Heidelberg, Germany
Heidelberg, Germany
Heidelberg, Germany
600 Massachusetts Ave NW #300, Washington, DC 20001
Institutions
University of Toronto
University of Calgary
UCalgary is on a mission to discover new knowledge and translate our discoveries into applications that provide benefits to our communities. The University of Calgary is one of Canada’s top comprehensive research universities, with a mission to discover new knowledge and translate our discoveries
Sick Kids
Hopp Children's Cancer Center
Genentech Inc
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