The study of a tumor’s immune repertoire includes an analysis of T cell receptors and B cell receptors that allow an immune system to adapt to changes and launch an immune system response. Understanding the immune repertoire of pediatric tumors could lead to advancements in immunotherapy, a therapy that uses a patient’s own immune system to attack a tumor. Researchers will analyze data from pediatric brain tumors through access to the Pediatric Brain Tumor Atlas in a search for relevant features of the immune system that could be utilized in new immunotherapies.
What are the goals of this project?
Researchers are looking to better understand the immune system of pediatric brain tumors through an analysis of T cell and B cell receptors.
What is the impact of this project?
An in-depth understanding of a tumor’s immune repertoire could guide researchers in developing treatments such as new immunotherapies.
Why is the CBTN request important to this project?
The broad set of data across pediatric brain tumor types provided through the Pediatric Brain Tumor Atlas is necessary to complete this work.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
- Arash Nabbi, PharmD, PhD - University Health Network
- Dr. Uri Tabori, MD - The Hospital for Sick Children
- Dr. Stefan Pfister, MD - Hopp-Children’s Cancer Center, Germany
- Dr. David Jones, PhD - Hopp-Children’s Cancer Center, Germany
- Dr. Jaeger, Hopp-Children’s Cancer Center, Germany
- Dr Katherine Hutchinson, PhD - Genentech
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Hopp Children's Cancer Center
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