Trevor Pugh

Low-grade gliomas are the most prevalent brain cancer among children. While patients with this type of cancer respond well to surgery, the majority experience recurrence after initial resection, requiring additional rounds of treatment that are rarely guided by molecular information. Intra-tumour

The goal of this study is to determine the overall layout of infiltrating immune repertoire in pediatric solid tumors. We will perform immune repertoire analysis and deconvolute immune components from RNA-seq data using transcript counts to infer the fraction of ~20 immune cell types infiltrating