Investigating the Immune Response in Pediatric Glioma Subsets

Email Principal Investigator

About this


Different tumors have different types of immune responses. We would like to better understand the drivers of this differential response so that we can best treat these tumors.

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What are the goals of this project?

The goal of this project is to investigate determinants of the tumor-associated immune response in pediatric lower grade glioma.

What is the impact of this project?

Our overall goal is to identify determinants of the immune microenvironment in glioma so that therapeutic strategies targeting the relevant pathways can be prioritized for the patients who are most likely to benefit.

Why the CBTN request is important to this project?

Using data from CBTN, we can investigate whether these mRNA and protein-level differences can be appreciated in a larger, unbiased data set when comparing specific molecular tumor subsets. Preliminary analyses of gene expression data in PedCBioPortal demonstrate a robust difference in the factors we are interested in.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas