Investigating the Immune Response in Pediatric Glioma Subsets

Email Principal Investigator
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Joanna Phillips

UCSF Benioff Children's Hospital
San Francisco and Oakland, CA, USA



Private Foundation

About this


The body’s immune response is how the body recognizes and defends itself against what it determines are foreign and harmful substances or microorganisms. Tumors have their own immune response that suppresses the normal body’s immune mechanisms, and different tumors have different types of immune responses. Researchers on this project seek to better understand the tumor-associated immune response in pediatric lower grade glioma. Preliminary analyses of gene expression data in PedCBioPortal demonstrated a robust difference in the factors researchers on this project are interested in. The overall goal of this project is to identify determinants of the immune microenvironment in glioma to better direct and prioritize treatments. Using data made accessible through the Pediatric Brain Tumor Atlas, researchers can investigate whether these differences are seen in a larger dataset, guiding further research.

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Ask the scientists

What are the goals of this project?

Researchers will investigate gene expression in pediatric glioma in an effort to better understand the disease.

What is the impact of this project?

Preliminary research has provided researchers with promising leads related to diagnostics and treatment options. This project will deepen this analysis by utilizing a much larger dataset.

Why is the CBTN request important to this project?

The large dataset made available through the Pediatric Brain Tumor Atlas will allow researchers to continue their investigations.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas